ArticleJournal of psychiatry & neuroscience : JPN2019
Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study
Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression.Journal of affective disorders · 2025Article
- The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence.Research square · 2025Article
- Altered Reward Processing in Obsessive-Compulsive Disorder: Insights From Active and Observational Learning.Psychophysiology · 2025Article
- Altered neural anticipation of reward and loss but not receipt in adolescents with obsessive-compulsive disorder.BMC psychiatry · 2024Article
- Altered dynamic functional and effective connectivity in drug-naive children with Tourette syndrome.Translational psychiatry · 2024Article
- Neural Processing Dysfunctions During Fear Learning but Not Reward-Related Processing Characterize Depressed Individuals With High Levels of Repetitive Negative Thinking.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Subcortical shape in pediatric and adult obsessive-compulsive disorder.Depression and anxiety · 2022Article
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
- Neuromodulation of OCD: A review of invasive and non-invasive methods.Frontiers in neurology · 2022Review
- Deep brain stimulation of the "medial forebrain bundle": a strategy to modulate the reward system and manage treatment-resistant depression.Molecular psychiatry · 2022Review
- Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective.Schizophrenia bulletin · 2021Article
- Adult Hippocampal Neurogenesis and Affective Disorders: New Neurons for Psychic Well-Being.Frontiers in neuroscience · 2021Review
- Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021Review
- Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders.NeuroImage. Clinical · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obsessive–compulsive disorder (OCD) is characterized by anxiety-provoking, obsessive thoughts. Patients usually react to these thoughts with repetitive behaviours that reduce anxiety and are perceived as rewarding. Hence, reward plays a major role in the psychopathology of OCD. Previous studies showed altered activation in frontostriatal networks, among others, in association with the processing of reward in patients with OCD. Potential alterations in connectivity within these networks have, however, barely been explored. Methods: We investigated a sample of patients with OCD and healthy controls using functional MRI and a reward learning task presented in an event-related design. Dynamic causal modelling (DCM) was used to estimate effective connectivity. Results: Our sample included 37 patients with OCD and 39 healthy controls. Analyses of task-related changes in connectivity showed a significantly altered effective connectivity between the ventromedial prefrontal cortex (vmPFC) and the orbitofrontal cortex (OFC), among others, both in terms of endogenous connectivity as well as modulatory effects under positive feedback. Clinical measures of compulsion correlated with the effect of feedback input on visual sensory areas. Limitations: The reported alterations should be interpreted within the context of the task and the a priori–defined network considered in the analysis. Conclusion: This disrupted connectivity in parts of the default mode network and the frontostriatal network may indicate increased rumination and self-related processing impairing the responsiveness toward external rewards. This, in turn, may underlie the general urge for reinforcement accompanying compulsive behaviours.
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