Evidence map›Paper›PMID 30964611›Full record

ArticleJournal of psychiatry & neuroscience : JPN2019

Nonacceptance of negative emotions in women with borderline personality disorder: association with neuroactivity of the dorsal striatum

Agnes Lamers, Max Toepper, Silvia Carvalho Fernando, Nicole Schlosser, Eva Bauer, Friedrich Woermann, Martin Driessen, Thomas Beblo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  7. Article
  8. Striatal Shati/Nat8l-BDNF pathways determine the sensitivity to social defeat stress in mice through epigenetic regulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Agnes LamersFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Max ToepperFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Silvia Carvalho FernandoFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Nicole SchlosserFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Eva BauerFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Friedrich WoermannFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Martin DriessenFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Thomas BebloFrom the Evangelisches Klinikum Bethel, Department of Psychiatry and Psychotherapy Bethel, Research Division, Germany (Lamers, Toepper, Fernando, Schlosser, Driessen, Beblo); the Bielefeld University, Department of Psychology, Beielefeld, Germany (Lamers, Driessen, Beblo); the University of Giessen, Cognitive Neuroscience at the Centre for Psychiatry, Germany (Bauer); and the Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany (Woermann).
Bethel University · USBielefeld University · DEHochschule Bielefeld · DEInstitut des Sciences Cognitives Marc Jeannerod · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Emotion dysfunction is a key symptom in patients with borderline personality disorder (BPD) and is considered a consequence of dysfunctional emotion regulation (e.g., reduced emotion acceptance). In the present functional MRI (fMRI) study, we investigated the neural correlates of habitual emotion acceptance in individuals with BPD. Methods: Female patients with BPD and female healthy controls passively viewed negative and neutral movie clips of faces during fMRI. We assessed emotion acceptance using the Emotion Acceptance Questionnaire (EAQ). To examine brain activation associated with habitual emotional acceptance of negative stimuli, the EAQ score was included as a regressor of interest in brain data analyses of activation intensity during negative compared with neutral movies. Results: We included 20 women with BPD and 20 heatlhy controls in our analysis. Compared with healthy controls, patients with BPD showed significantly more activation in frontostriatal brain regions (i.e., left superior frontal gyrus, right caudate) as well as in the left precuneus, left precentral gyrus, left posterior cingulate cortex and left hippocampus when confronted with negative (v. neutral) stimuli. Patients with BPD reported decreased emotion acceptance compared with healthy controls, and habitual emotion acceptance was inversely associated with activation of striatal areas (i.e., left putamen, left caudate) in patients with BPD. Limitations: Causal conclusions are not possible. Comorbid diagnoses were not excluded, and only female participants were investigated. Stimuli were not rated immediately and may not be generalizable to all negative emotions. We cannot make any statements about other emotion-regulation strategies that may have been applied here. Conclusion: Data indicate that striatal hyperactivation during the processing of negative stimuli in women with BPD is related to their decreased disposition to accept unpleasant emotional states. Thus, individuals with BPD may benefit from therapy approaches that focus on emotion acceptance in order to normalize emotional reactions.

Indexed as

AdultBehaviorBorderline Personality DisorderBrainCase-Control StudiesCaudate NucleusCerebral CortexEmotional RegulationFemaleFrontal LobeFunctional NeuroimagingGyrus CinguliHippocampusHumansMagnetic Resonance ImagingNeostriatum

Identifiers

PMID30964611
PMCPMC6710090
OpenAlexW2970519210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.