ArticleRadiology2019
Longitudinal Characterization of Cortical Lesion Development and Evolution in Multiple Sclerosis with 7.0-T MRI.
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In one paragraph
Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies.PloS one · 2024Pooled it
- Imaging cortical multiple sclerosis lesions with ultra-high field MRI.NeuroImage. Clinical · 2021Pooled it
- Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.Clinical radiology · 2019Pooled it
- Cortical lesions in multiple sclerosis: 25 years of progress, remaining challenges and future directions.Nature reviews. Neurology · 2026Review
- Following the curvature: Sulcal versus gyral cortical localization of cerebral microbleeds in cerebral amyloid angiopathy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Clinical course of critical demyelinating lesion-associated progressive multiple sclerosis.Journal of neurology · 2026Article
- Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.Communications medicine · 2026Article
- Cortical Lesions Form Predominantly in Early Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2026Article
- Superiority of 3D-DIR over 3D-FLAIR in the Detection of Cortical Lesions and Correlation with Disability in Multiple Sclerosis: A Multicenter Study.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- Evolving the Diagnosis of Multiple Sclerosis: A New Landscape in Light of the 2024 McDonald Criteria.Biomedicines · 2025Review
- Refining Prognostic Factors in Adult-Onset Multiple Sclerosis: A Narrative Review of Current Insights.International journal of molecular sciences · 2025Review
- Evolution of Cortical Lesions and Function-Specific Cognitive Decline in People With Multiple Sclerosis.Neurology · 2025Article
- Biomarkers of Progression Independent of Relapse Activity-Can We Actually Measure It Yet?International journal of molecular sciences · 2025Review
- Novel serum biomarker associations with 7 Tesla MRI-defined cortical lesions, leptomeningeal enhancement, and deep gray matter volume in early multiple sclerosis.Scientific reports · 2025Article
- Clinical 7 Tesla magnetic resonance imaging: Impact and patient value in neurological disorders.Journal of internal medicine · 2025Review
- Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex.Annals of clinical and translational neurology · 2025Article
- Efficacy of rituximab in secondary progressive multiple sclerosis: Insights from magnetic resonance imaging and disability assessments.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Leveraging hand-crafted radiomics on multicenter FLAIR MRI for predicting disability worsening in people with multiple sclerosis.Frontiers in neuroscience · 2025Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Constantina A TreabaFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).ORCID 0000-0001-8260-207X
Tobias E GranbergFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).
Maria Pia SormaniFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).
Elena HerranzFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).ORCID 0000-0001-7207-6811
Russell A OuelletteFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).ORCID 0000-0001-9217-1445
Céline LouapreFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).ORCID 0000-0003-0214-4617
Jacob A SloaneFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).
Revere P KinkelFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).
Caterina MaineroFrom the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg 149, 13th St, Charleston, MA 02129 (C.A.T., T.E.G., E.H., R.A.O., C.L., C.M.); Harvard Medical School, Boston, MA (C.A.T., T.E.G., E.H., C.L., C.M.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (T.E.G.); Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy (M.P.S.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (J.A.S.); and Department of Neurosciences, University of California San Diego, San Diego, CA (R.P.K.).ORCID 0000-0003-3244-8507
Harvard University · USAthinoula A. Martinos Center for Biomedical Imaging · USBeth Israel Deaconess Medical Center · USUniversity of California San Diego · US
Funding
Cortical mechanisms of disease progression in early multiple sclerosisR01NS078322 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2013 to 2017
$1.9MNINDS NIH HHS R01 NS078322
Abstract
Background Cortical lesions develop early in multiple sclerosis (MS) and play a major role in disease progression. MRI at 7.0 T shows high sensitivity for detection of cortical lesions as well as better spatial resolution and signal-to-noise ratio compared with lower field strengths. Purpose To longitudinally characterize
Indexed as
Cerebral CortexMultiple SclerosisAdultDisease ProgressionFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesWhite Matter
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.