ArticleIET nanobiotechnology2019
Functionalisation of carbon nanotubes by methotrexate and study of synchronous photothermal effect of carbon nanotube and anticancer drug on cancer cell death.
Article in IET nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 17 citations in OpenAlex.
- Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulatingRSC advances · 2026Article
- Review
- Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study.Archives of toxicology · 2024Article
- Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes.Materials (Basel, Switzerland) · 2021Review
- Synthesis, Characterization, Cellular Uptake, andFrontiers in pharmacology · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carboxylated functionalised multi-walled carbon nanotubes (f-MWCNT) were synthesised. Furthermore, folic acid (FA) and methotrexate (MTX) through ethylenediamine (ED) were attached to the surface of f-MWCNT to synthesise MWCNT-ED-FA and MWCNT-ED-MTX. Release studies of MTX as free drug and in MWCNT-ED-MTX were performed. These studies showed that MTX release rate from MWCNT-ED-MTX decreased in comparison with free MTX, which is due to the MTX attachment on the MWCNT. The anticancer effect of MWCNT-ED-FA and MWCNT-ED-MTX on the breast cancer cell line (MCF-7) was studied. Studies have shown that MWCNT-ED-MTX cytotoxicity is more than that of MWCNT-ED-FA, which is due to the presence of MTX. Furthermore, the anticancer effects of MWCNT-ED-FA and MWCNT-ED-MTX in the presence of infrared laser radiation on the MCF7 cell were studied. The experiments showed that in the presence of the laser, the cytotoxicities of MWCNT-ED-FA and MWCNT-ED-MTX were the same and increased in comparison with laser absence, which indicates that the photothermal effect is stronger than other factors and mask their effects. This effect can be related to laser radiation absorption by MWCNT and its conversion to heat which can induce cancer cell death. Targeting studies have shown that MWCNT-ED-FA is targeted to the cancer cells due to the presence of FA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.