Evidence map›Paper›PMID 30963998›Full record

ArticleeLife2019

Plasticity of

Elizabeth A Mueller, Alexander Jf Egan, Eefjan Breukink, Waldemar Vollmer, Petra Anne Levin

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Non-canonical peptidoglycan cross-linking is essential forbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  10. Article
  11. Article
  12. Polyphasic taxonomy and genome mining ofCurrent research in microbial sciences · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Penicillin-binding protein redundancy inApplied and environmental microbiology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Elizabeth A MuellerDepartment of Biology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0001-5482-6551
Alexander Jf EganCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Eefjan BreukinkMembrane Biochemistry and Biophysics, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Waldemar VollmerCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Petra Anne LevinDepartment of Biology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0003-2071-0547
Newcastle University · GBWashington University in St. Louis · USUtrecht University · NL

Funding

HOMEOSTATIC CONTROL OF BACTERIAL GROWTH AND CELL DIVISIONR35GM127331 · NIGMS · WASHINGTON UNIVERSITY · PI Petra Anne Levin · 2018 to 2026
$4.3M
TEMPORAL AND SPATIAL CONTROL OF B SUBTILIS CYTOKINESISR01GM064671 · NIGMS · WASHINGTON UNIVERSITY · PI LEVIN, PETRA ANNE · 2002 to 2016
$3.9M
National Science Foundation DGE-1745038NIGMS NIH HHS R01 GM064671NIGMS NIH HHS R35 GM127331NIH HHS GM127331NIH HHS GM64671Wellcome 101824/Z/13/ZWellcome Trust
6 · The paper itself

Abstract

Although the peptidoglycan cell wall is an essential structural and morphological feature of most bacterial cells, the extracytoplasmic enzymes involved in its synthesis are frequently dispensable under standard culture conditions. By modulating a single growth parameter-extracellular pH-we discovered a subset of these so-called 'redundant' enzymes in Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Indexed as

Drug Resistance, BacterialCell WallEscherichia coliHydrogen-Ion ConcentrationPenicillin-Binding ProteinsPeptidoglycanPenicillin-Binding ProteinsPeptidoglycanbeta-lactam antibioticsE. coliinfectious diseasemicrobiologypenicillin binding proteinsPeptidoglycanpHredundancy

Identifiers

PMID30963998
PMCPMC6456298
OpenAlexW2939226595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.