ArticleProceedings. Biological sciences2018
Autism sensory dysfunction in an evolutionarily conserved system.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG.Autism research : official journal of the International Society for Autism Research · 2026Article
- Effects of Memantine on the Auditory Steady-State and Harmonic Responses to 40 Hz Stimulation Across Species.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Temporal dynamics of normalization reweighting.Journal of vision · 2023Article
- Steady-state visual evoked potentials in children with neurofibromatosis type 1: associations with behavioral rating scales and impact of psychostimulant medication.Journal of neurodevelopmental disorders · 2022Article
- Gene editing in monogenic autism spectrum disorder: animal models and gene therapies.Frontiers in molecular neuroscience · 2022Review
- Power contours: Optimising sample size and precision in experimental psychology and human neuroscience.Psychological methods · 2021Article
- A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.Journal of vision · 2021Article
- ModelingFrontiers in cellular neuroscience · 2021Review
- Natural history of social and sexual behavior in fruit flies.Scientific reports · 2020Article
- Reduced auditory steady state responses in autism spectrum disorder.Molecular autism · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
There is increasing evidence for a strong genetic basis for autism, with many genetic models being developed in an attempt to replicate autistic symptoms in animals. However, current animal behaviour paradigms rarely match the social and cognitive behaviours exhibited by autistic individuals. Here, we instead assay another functional domain-sensory processing-known to be affected in autism to test a novel genetic autism model in Drosophila melanogaster. We show similar visual response alterations and a similar development trajectory in Nhe3 mutant flies (total n = 72) and in autistic human participants (total n = 154). We report a dissociation between first- and second-order electrophysiological visual responses to steady-state stimulation in adult mutant fruit flies that is strikingly similar to the response pattern in human adults with ASD as well as that of a large sample of neurotypical individuals with high numbers of autistic traits. We explain this as a genetically driven, selective signalling alteration in transient visual dynamics. In contrast to adults, autistic children show a decrease in the first-order response that is matched by the fruit fly model, suggesting that a compensatory change in processing occurs during development. Our results provide the first animal model of autism comprising a differential developmental phenotype in visual processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.