ArticleProceedings. Biological sciences2018
Ultra-high matrix mineralization of sperm whale auditory ossicles facilitates high sound pressure and high-frequency underwater hearing.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 21 citations in OpenAlex.
- Vowel- and Diphthong-Like Spectral Patterns in Sperm Whale Codas.Open mind : discoveries in cognitive science · 2025Article
- In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution.JBMR plus · 2024Article
- Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced osteomalacia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Influence of X-rays and gamma-rays on the mechanical performance of human bone factoring out intraindividual bone structure and composition indices.Materials today. Bio · 2022Article
- Prevention of Hypomineralization In Auditory Ossicles of Vitamin D Receptor (Vdr) Deficient Mice.Frontiers in endocrinology · 2022Article
- Conductive Hearing Loss in the Hyp Mouse Model of X-Linked Hypophosphatemia Is Accompanied by Hypomineralization of the Auditory Ossicles.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Micropetrosis in hemodialysis patients.Bone reports · 2021Article
- Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Early Changes in Cement-Bone Fixation Using a Novel Rat Knee Replacement Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
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10 authors at 2 institutions in 1 country.
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Abstract
The auditory ossicles-malleus, incus and stapes-are the smallest bones in mammalian bodies and enable stable sound transmission to the inner ear. Sperm whales are one of the deepest diving aquatic mammals that produce and perceive sounds with extreme loudness greater than 180 dB and frequencies higher than 30 kHz. Therefore, it is of major interest to decipher the microstructural basis for these unparalleled hearing abilities. Using a suite of high-resolution imaging techniques, we reveal that auditory ossicles of sperm whales are highly functional, featuring an ultra-high matrix mineralization that is higher than their teeth. On a micro-morphological and cellular level, this was associated with osteonal structures and osteocyte lacunar occlusions through calcified nanospherites (i.e. micropetrosis), while the bones were characterized by a higher hardness compared to a vertebral bone of the same animals as well as to human auditory ossicles. We propose that the ultra-high mineralization facilitates the unique hearing ability of sperm whales. High matrix mineralization represents an evolutionary conserved or convergent adaptation to middle ear sound transmission.
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