ArticleProceedings. Biological sciences2018
Insulin signalling's role in mediating tissue-specific nutritional plasticity and robustness in the horn-polyphenic beetle Onthophagus taurus.
Article in Proceedings. Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 62 citations in OpenAlex.
- Duplicated paralog of insulin receptor functions distinctively in locust reproduction for high fecundity.Insect science · 2026Article
- Opposing insulin signals underlie the same developmental switch across hemipteran insects.Science advances · 2026Article
- Transcriptomic basis underlying the evolution of female horn plasticity in scarab beetles.Frontiers in zoology · 2026Article
- Insulin-like peptide has antagonistic pleiotropic effects on male combat traits and survival traits in an armed beetle.The Journal of experimental biology · 2026Article
- Cryptic genetic variation in brain gene expression precedes the evolution of cannibalism in spadefoot toad tadpoles.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular mechanisms underlying the evolution of a color polyphenism by genetic accommodation in the tobacco hornworm,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Genome evolution and divergence in cis-regulatory architecture is associated with condition-responsive development in horned dung beetles.PLoS genetics · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Gene regulatory networks underlying the development and evolution of plasticity in horned beetles.Current opinion in insect science · 2023Review
- Transcriptomic and functional screening of weapon formation genes implies significance of cell adhesion molecules and female-biased genes in broad-horned flour beetle.PLoS genetics · 2023Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Mitochondria dysfunction impairs Tribolium castaneum wing development during metamorphosis.Communications biology · 2022Article
- Developmental bias in the evolution and plasticity of beetle horn shape.Proceedings. Biological sciences · 2022Article
- The Insulin Receptor: An Important Target for the Development of Novel Medicines and Pesticides.International journal of molecular sciences · 2022Review
- Comparative metabolomic analysis of polyphenic horn development in the dung beetle Onthophagus taurus.PloS one · 2022Article
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- Neofunctionalization of a second insulin receptor gene in the wing-dimorphic planthopper, Nilaparvata lugens.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Organisms cope with nutritional variation via developmental plasticity, adjusting trait size to nutrient availability for some traits while enabling others to develop in a nutritionally robust manner. Yet, the developmental mechanisms that regulate organ-specific growth across nutritional gradients remain poorly understood. We assessed the functions of members of the insulin/insulin-like signalling pathway (IIS) in the regulation of nutrition sensitivity and robustness in males of the horn-polyphenic beetle Onthophagus taurus, as well as potential regulatory interactions between IIS and two other growth-regulating pathways: Doublesex and Hedgehog signalling. Using RNA interference (RNAi), we experimentally knocked down both insulin receptors ( InR1 and InR2) and Foxo, a growth inhibitor. We then performed morphometric measurements on horns, a highly nutrition-sensitive trait, and genitalia, a largely nutrition-insensitive trait. Finally, we used quantitative real-time polymerase chain reaction to assess expression levels of doublesex and the Hedgehog signalling gene smoothened following IIS-RNAi. Our results suggest that nutrition responsiveness of both traits is regulated by different IIS components, which transduce nutritional conditions to both Doublesex and Hedgehog pathways, albeit via different IIS pathway members. Combined with previous studies, our findings suggest that separate origins of trait exaggeration among insect lineages were enabled through the independent co-option of IIS, yet via reliance on different components therein.
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