Evidence map›Paper›PMID 30963760›Full record

ArticleAnalytical chemistry2019

A Single Approach Reveals the Composite Conformational Changes, Order of Binding, and Affinities for Calcium Binding to Calmodulin.

Xiaoran Roger Liu, Mengru Mira Zhang, Don L Rempel, Michael L Gross

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Conformation-Specific Approach to Native Top-down Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024
    Article
  5. Article
  6. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Protein-Ligand Affinity Determinations Using Covalent Labeling-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2020
    Article
  17. Review
  18. CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Xiaoran Roger LiuDepartment of Chemistry , Washington University in St. Louis , One Brookings Drive , St. Louis , Missouri 63130 , United States.ORCID 0000-0003-3198-1588
Mengru Mira ZhangDepartment of Chemistry , Washington University in St. Louis , One Brookings Drive , St. Louis , Missouri 63130 , United States.ORCID 0000-0001-9082-1272
Don L RempelDepartment of Chemistry , Washington University in St. Louis , One Brookings Drive , St. Louis , Missouri 63130 , United States.
Michael L GrossDepartment of Chemistry , Washington University in St. Louis , One Brookings Drive , St. Louis , Missouri 63130 , United States.ORCID 0000-0003-1159-4636
Washington University in St. Louis · US

Funding

TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
A MASS SPECTROMETER FOR PROTEIN FOOTPRINTINGS10OD016298 · OD · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2014 to 2014
$450k
NIGMS NIH HHS P41 GM103422NIH HHS S10 OD016298
6 · The paper itself

Abstract

We found that a newly developed method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and mass spectrometry) can characterize section-by-section of a protein the conformational changes induced by metal-ion binding. Peptide-level LITPOMS applied to Ca

Indexed as

CalciumCalmodulinModels, MolecularProtein BindingProtein ConformationCalciumCalmodulin

Identifiers

PMID30963760
PMCPMC6506365
OpenAlexW2936610349

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.