ArticlePhysiological reports2019
Chronic infusion of interleukin-17 promotes hypertension, activation of cytolytic natural killer cells, and vascular dysfunction in pregnant rats.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06281262 (The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia), which is not on this map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia
Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Interleukin-6 Downregulates T Helper 17 Cytokines via Indoleamine 2,3-Dioxygenase 1 at the Maternal-Fetal Interface.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Article
- Bushen Huoxue Recipe enhances the immune microenvironment at the maternal-fetal interface via the Hippo signaling pathway in mice with recurrent spontaneous abortion.Journal of traditional and complementary medicine · 2026Article
- Interleukin-1 receptor type 1 inhibition improves blood pressure, fetal growth and immune balance in placental ischemic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025Review
- Mineralocorticoid receptor antagonists promote renal immunosenescence.International urology and nephrology · 2025Review
- Understanding the role of immune-mediated inflammatory disease related cytokines interleukin 17 and 23 in pregnancy: A systematic review.Journal of translational autoimmunity · 2025Review
- Beta 2 adrenergic receptor gene methylation activates innate lymphoid cells to drive hypertension in lymphocyte deficient hosts.Cardiovascular research · 2025Article
- Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).International journal of molecular medicine · 2025Review
- Distinct phenotypes in the preeclamptic-like mouse model induced by adenovirus carrying sFlt1 and recombinant sFlt1 protein.European journal of medical research · 2024Article
- Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Effect of Granzyme K, FasL and Interferon-γ Expression in Placentas with Preeclampsia.Biomedicines · 2024Article
- IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia.American journal of physiology. Heart and circulatory physiology · 2024Article
- Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.American journal of obstetrics and gynecology · 2024Article
- The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Inhibition of Caspase 1 Reduces Blood Pressure, Cytotoxic NK Cells, and Inflammatory T-Helper 17 Cells in Placental Ischemic Rats.International journal of molecular sciences · 2024Article
- Mechanisms of inflammation modulation by different immune cells in hypertensive nephropathy.Frontiers in immunology · 2024Review
- VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.Current opinion in physiology · 2023Article
- RUPP Th17s cause hypertension and mitochondrial dysfunction in the kidney and placenta during pregnancy.Pregnancy hypertension · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Olivia K TravisDepartment of Experimental Therapeutics and Pharmacologyogy, University of Mississippi Medical Center, Jackson, Mississippi.
Dakota WhiteDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
W Austin PierceDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Ying GeDepartment of Surgery, University of Mississippi Medical Center, Jackson, Mississippi.
Cassandra Y StubbsDepartment of Experimental Therapeutics and Pharmacologyogy, University of Mississippi Medical Center, Jackson, Mississippi.
Frank T SpradleyDepartment of Surgery, University of Mississippi Medical Center, Jackson, Mississippi.
Jan M WilliamsDepartment of Experimental Therapeutics and Pharmacologyogy, University of Mississippi Medical Center, Jackson, Mississippi.
Denise C CorneliusDepartment of Experimental Therapeutics and Pharmacologyogy, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-6730-6499
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · US
Funding
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4MMechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7MEffect of obesity on antiangiogenic and inflammatory mechanisms of hypertensionR00HL130577 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI SPRADLEY, FRANK TRAVIS · 2017 to 2019
$747kHypertension and InflammationR00HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2017 to 2019
$747kNHLBI NIH HHS R00 HL130456NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM104357NIH HHS P20GM104357NIH HHS R00HL130456NIH HHS R00HL130577NIH HHS R01DK109133
Abstract
Previous studies by our lab have established that placental-ischemia stimulated T-helper 17 cells (T
Indexed as
AnimalsBlood PressureFemaleGranzymesHypertensionInterleukin-17Killer Cells, NaturalPlacentaPregnancyRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaUterine ArteryUterusVascular Endothelial Growth Factor AGranzymesInterleukin-17Tumor Necrosis Factor-alphaVascular Endothelial Growth Factor AHypertensionIL-17natural killer cellspregnancyvascular reactivity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06281262ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.