Evidence map›Paper›PMID 30963653›Full record

ArticleJournal of neuroendocrinology2019

Role of the posterodorsal medial amygdala in predator odour stress-induced puberty delay in female rats.

Xiao Feng Li, Daniel A Adekunbi, Hussah M Alobaid, Shengyun Li, Michel Pilot, Stafford L Lightman, Kevin T O'Byrne

Open access · hybridAbstract read
In one paragraph

Article in Journal of neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiao Feng LiDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Daniel A AdekunbiDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Hussah M AlobaidDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Shengyun LiDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Michel PilotDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Stafford L LightmanHenry Wellcome Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK.ORCID 0000-0002-8546-9646
Kevin T O'ByrneDepartment of Women and Children's Health, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0002-2548-4182
King's College London · GBUniversity of Bristol · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/N022637/1
6 · The paper itself

Abstract

Puberty onset is influenced by various factors, including psychosocial stress. The present study investigated cat-odour stress on puberty onset and oestrous cyclicity in rats. Female weanling rats were exposed to either soiled cat litter or fresh unused litter for 10 consecutive days. Following vaginal opening (VO), rats were smeared for 14 days to determine oestrous cyclicity. Anxiety-like behaviour was assessed using standard anxiety tests. Brains were collected to determine corticotrophin-releasing factor (CRF), CRF receptor 1 (CRF-R1) and CRF receptor 2 (CRF-R2) mRNA in the paraventricular nucleus (PVN), as well as the central nucleus of the amygdala (CEA) and the medial nucleus of the amygdala (MEA). Cat odour delayed VO and first oestrus, disrupted oestrous cycles and caused anxiogenic responses. Cat odour elicited increased CRF mRNA expression in the PVN but not in the CeA. CRF-R1 and CRF-R2 mRNA levels in the PVN and CeA were unaffected by cat odour; however, CRF-R1 mRNA levels were decreased in the MeA. The role of CRF signalling in the MeA, particularly its posterodorsal subnucleus (MePD), with respect to pubertal timing was directly examined by unilateral intra-MePD administration of CRF (0.2 nmol day

Indexed as

AnimalsAnxietyCentral Amygdaloid NucleusCorticomedial Nuclear ComplexCorticotropin-Releasing HormoneCRF Receptor, Type 1Estrous CycleFemaleParaventricular Hypothalamic NucleusRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneSexual MaturationSignal TransductionSocial BehaviorStress, PsychologicalCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2Receptors, Corticotropin-Releasing HormoneamygdalaCRFpredatorpubertystress

Identifiers

PMID30963653
PMCPMC6563483
OpenAlexW2937584774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.