ArticleThe Laryngoscope2020
Assessing fractional hair cell survival in archival human temporal bones.
Article in The Laryngoscope, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Greater Cochlear Damage in Otogenic Versus Meningogenic Meningitis: Hearing Rehabilitation Implications.The Laryngoscope · 2026Article
- Cochlear Neural Degeneration Is Widespread in Ménière's Disease: A Temporal Bone Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Cochlear neural degeneration is key to the variation in word scores among people with similar thresholds.Hearing research · 2026Article
- Anatomical Integrity of the Human Cochlea Estimated with Optical Coherence Tomography for Future Clinical Application.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Identification of sensorineural hearing loss subtypes using unsupervised machine learning and assessment of their replicability.Scientific reports · 2026Article
- Hair cell loss - cause or consequence of hearing loss?Frontiers in cell and developmental biology · 2026Review
- Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing.Communications biology · 2025Article
- Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application.bioRxiv : the preprint server for biology · 2025Article
- Delayed hearing loss after cochlear implantation: Re-evaluating the role of hair cell degeneration.Hearing research · 2024Article
- Ossicular joint histopathology in cases of age-related hearing loss.Laryngoscope investigative otolaryngology · 2024Article
- Predicting Atrophy of the Cochlear Stria Vascularis from the Shape of the Threshold Audiogram.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural Degeneration in Normal-Aging Human Cochleas: Machine-Learning Counts and 3D Mapping in Archival Sections.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies.Hearing research · 2023Article
- Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies.bioRxiv : the preprint server for biology · 2023Article
- Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing.Hearing research · 2023Article
- The effects of mild hypothermia on the electrode insertion trauma in a murine whole organ cochlea culture.Frontiers in neuroscience · 2023Article
- Article
- Age-related stereocilia pathology in the human cochlea.Hearing research · 2022Article
- Current topics in hearing research: Deafferentation and threshold independent hearing loss.Hearing research · 2022Review
- Modeling the effects of age and hearing loss on concurrent vowel scores.The Journal of the Acoustical Society of America · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectives/hypothesisHistopathological analysis of hair cell survival in human temporal bone sections has historically been binarized such that each hair cell row is rated as either present or absent, thereby greatly underestimating the amount of hair cell loss. Here, we describe and validate a technique to reliably assess fractional hair cell survival in archival sections stained with hematoxylin and eosin (H&E) using high-resolution light microscopy and optical sectioning. STUDY
designTechnique validation.
methodsHair cell counts in archival temporal bone slide sets were performed by several observers using either differential interference contrast (DIC) or confocal microscopy of the endogenous eosin fluorescence in hair cells. As a further cross-check, additional decelloidinized sections were immunostained with hair cell markers myosin VI and VIIa.
resultsCuticular plates and stereocilia bundles are routinely resolvable in DIC imaging of archival H&E-stained human material using standard research-grade microscopes, allowing highly accurate counts of fractional hair cell survival that are reproducible across observer and can be verified by confocal microscopy.
conclusionsReanalysis of cases from the classic temporal bone literature on presbycusis suggests that, contrary to prior reports, differences in audiometric patterns may be well explained by the patterns of hair cell loss. LEVEL OF EVIDENCE: NA Laryngoscope, 130:487-495, 2020.
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