ArticleJournal of endocrinological investigation2019
Evaluation of the NOX5 protein expression and oxidative stress in sperm from asthenozoospermic men compared to normozoospermic men.
Article in Journal of endocrinological investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Oxidative Stress and Male Infertility: A Critical Analysis of Current Diagnostic and Therapeutic Methods.Antioxidants (Basel, Switzerland) · 2026Review
- Molecular Advances in Male Infertility and Fertility: Importance of Redox Regulation and Oxidative Stress.International journal of molecular sciences · 2026Review
- Sphingolipids modulate redox signalling during human sperm capacitation.Human reproduction (Oxford, England) · 2025Article
- Towards the Development of Novel, Point-of-Care Assays for Monitoring Different Forms of Antioxidant Activity: The RoXstaAntioxidants (Basel, Switzerland) · 2024Article
- A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.Heliyon · 2024Review
- A novel monoclonal antibody reveals the enrichment of NADPH oxidase 5 in human splenic endothelial cells.Scientific reports · 2023Article
- Calpain Regulates Reactive Oxygen Species Production during Capacitation through the Activation of NOX2 and NOX4.International journal of molecular sciences · 2023Article
- NADPH Oxidase-Mediated Testicular Oxidative Imbalance Regulates the TXNIP/NLRP3 Inflammasome Axis Activation after Ischemia Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2023Article
- Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Cryopreservation of Gametes and Embryos and Their Molecular Changes.International journal of molecular sciences · 2021Review
- Sperm Oxidative Stress during In Vitro Manipulation and Its Effects on Sperm Function and Embryo Development.Antioxidants (Basel, Switzerland) · 2021Review
- Genetics and molecular biology of male infertility among Iranian population: an update.American journal of translational research · 2021Review
- Skeletal muscle redox signaling in rheumatoid arthritis.Clinical science (London, England : 1979) · 2020Review
- The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility-A Unifying Hypothesis?Frontiers in endocrinology · 2020Review
- From Past to Present: The Link Between Reactive Oxygen Species in Sperm and Male Infertility.Antioxidants (Basel, Switzerland) · 2019Review
- Association of NOX5 Expression with Sperm Activity and Motility in Pathospermic Infertile Men.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
purposeNADPH oxidase 5 (NOX5), the main isoform of NOX in spermatozoa, has been recognized as the main active generators of reactive oxygen species (ROS), including superoxide anion (O
methodsSemen samples were collected from 25 asthenozoospermic men and 28 normozoospermic men. In this study, NOX5 protein expression was evaluated by Western blotting. An OS status was evaluated by measuring of ROS (O
resultsThe protein expression of NOX5 (p < 0.0001) was remarkably higher in asthenozoospermic men in comparison to normozoospermic men. In addition, the percentages of intracellular O
conclusionsThe present study provides evidence that the overexpression of NOX5 protein may induce excessive ROS production and oxidative stress damages to DNA and plasma membrane integrity in asthenozoospermic men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.