Evidence map›Paper›PMID 30963410›Full record

Trial reportBiological trace element research2020

The Effects of Selenium Supplementation on Clinical Symptoms and Gene Expression Related to Inflammation and Vascular Endothelial Growth Factor in Infertile Women Candidate for In Vitro Fertilization.

Zahra Heidar, Negar Hamzepour, Shahrzad Zadeh Modarres, Masoomeh Mirzamoradi, Esmat Aghadavod, Mohammad Hossein Pourhanifeh, Zatollah Asemi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Biological trace element research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2020
    Pooled it
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zahra HeidarInfertility and Reproductive Health Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Negar HamzepourInfertility and Reproductive Health Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahrzad Zadeh ModarresLaser Application in Medical Science Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoomeh MirzamoradiInfertility and Reproductive Health Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Esmat AghadavodResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
Mohammad Hossein PourhanifehResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
Zatollah AsemiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran. asemi_r@yahoo.com.ORCID http://orcid.org/0000-0001-5265-4792
Shahid Beheshti University of Medical Sciences · IRKashan University of Medical Sciences · IR

Funding

Shahid Beheshti University of Medical Sciences 9711015
6 · The paper itself

Abstract

This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. RT-PCR findings indicated that selenium supplementation downregulated gene expression of interleukin-1 (IL-1) (P < 0.004) and tumor necrosis factor alpha (TNF-α) (P = 0.02) in lymphocytes of patients with PCOS compared with the placebo. In addition, selenium supplementation upregulated gene expression of vascular endothelial growth factor (VEGF) (P = 0.001) in lymphocytes of patients with PCOS compared with the placebo. Selenium supplementation had no significant effect on clinical symptoms and gene expression of IL-8 (P = 0.10) and transforming growth factor beta (TGF-β) (P = 0.63). Overall, our findings documented that selenium supplementation for 8 weeks to infertile women candidate for IVF improved IL-1, TNF-α, and VEGF gene expression, though selenium had no effect on clinical symptoms and, IL-8 and TGF-β gene expression. Clinical trial registration number: http://www.irct.ir: IRCT20170513033941N23.

Indexed as

Fertilization in VitroAdultDietary SupplementsDouble-Blind MethodFemaleGene ExpressionHumansInfertility, FemaleInflammationInterleukin-1LymphocytesPolycystic Ovary SyndromeReverse Transcriptase Polymerase Chain ReactionSeleniumTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AInterleukin-1SeleniumTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AGene expressionInflammatory markersPolycystic ovary syndromeSelenium

Identifiers

PMID30963410
OpenAlexW2939678035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.