Evidence map›Paper›PMID 30963321›Full record

Trial reportAIDS and behavior2019

Antiretroviral Adherence Following Prison Release in a Randomized Trial of the imPACT Intervention to Maintain Suppression of HIV Viremia.

Bethany L DiPrete, Brian W Pence, Carol E Golin, Kevin Knight, Patrick M Flynn, Jessica Carda-Auten, Jennifer S Groves, Kimberly A Powers, Becky L White, Sonia Napravnik and 1 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Bethany L DiPreteDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, Chapel Hill, NC, 27599, USA. diprete@email.unc.edu.ORCID http://orcid.org/0000-0003-1298-4433
Brian W PenceDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, Chapel Hill, NC, 27599, USA.
Carol E GolinDepartment of Health Behavior, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin KnightThe Institute of Behavioral Research, Texas Christian University, Fort Worth, TX, USA.
Patrick M FlynnThe Institute of Behavioral Research, Texas Christian University, Fort Worth, TX, USA.
Jessica Carda-AutenThe Institute for Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jennifer S GrovesThe Cecil G. Sheps Center for Health Services Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kimberly A PowersDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, Chapel Hill, NC, 27599, USA.
Becky L WhiteThe Institute for Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sonia NapravnikDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, Chapel Hill, NC, 27599, USA.
David A WohlThe Institute for Global Health and Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USTexas Christian University · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Justice Community Opioid Innovation Network (JCOIN): TCU Clinical Research CenterUG1DA050074 · NIDA · TEXAS CHRISTIAN UNIVERSITY · PI KNIGHT, DANICA K, KNIGHT, KEVIN · 2019 to 2023
$10.1M
RCT of an augmented test, treat, link, & retain model for NC and Texas prisonersR01DA030793 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FLYNN, PATRICK M, GOLIN, CAROL E · 2010 to 2015
$6.9M
Mentoring New Investigators in Criminal Justice HIV Prevention and TreatmentK24DA037101 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOHL, DAVID A · 2014 to 2018
$911k
Mentoring Junior Investigators: Comprehensive HIV PreventionK24HD069204 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOLIN, CAROL E · 2013 to 2017
$789k
Center for AIDS Research, University of North Carolina at Chapel Hill P30 AI-50410Eunice Kennedy Shriver National Institute of Child Health and Human Development K24-DA037101Eunice Kennedy Shriver National Institute of Child Health and Human Development K24-HD06920National Institute of Allergy and Infectious Diseases T32-AI007001NIAID NIH HHS P30 AI050410NIAID NIH HHS T32 AI007001NICHD NIH HHS K24 HD069204NIDA NIH HHS K24 DA037101NIDA NIH HHS R01 DA030793NIDA NIH HHS R01-DA030793
6 · The paper itself

Abstract

Many people living with HIV (PLWH) pass through correctional facilities each year, a large proportion of whom do not maintain viral suppression following release. We examined the effects of imPACT, an intervention designed to promote post-release viral suppression, on antiretroviral therapy (ART) adherence. PLWH awaiting release from prisons in two southern states were randomized to imPACT (consisting of motivational interviewing, care linkage coordination, and text message medication reminders) versus standard care (SC). ART adherence, measured by unannounced monthly telephone pill counts, was compared between study arms over 6 months post-release. Of 381 participants eligible for post-release follow-up, 302 (79%) completed ≥ 1 of 6 possible pill counts (median: 4; IQR 1-6). Average adherence over follow-up was 80.3% (95% CI 77.5, 83.1) and 81.0% (78.3, 83.6) of expected doses taken in the imPACT and SC arms, respectively. There was no difference between arms when accounting for missing data using multiple imputation (mean difference = - 0.2 percentage points [- 3.7, 3.3]), controlling for study site and week of follow-up. Of the 936 (40.9%) pill counts that were missed, 212 (22.7%) were due to re-incarceration. Those who missed pill counts for any reason were more likely to be unsuppressed, suggesting that they had lower adherence. However, missingness was balanced between arms. Among PLWH released from prison, ART adherence averaged > 80% in both study arms over 6 months-a level higher than seen with most other chronic diseases. However, missing data may have led to an overestimate of adherence. Factors independent of the intervention influence ART adherence in this population and should be identified to inform future targeted interventions.

Indexed as

Antiretroviral Therapy, Highly ActiveDrug MonitoringAdultAnti-Retroviral AgentsContinuity of Patient CareFemaleHIV InfectionsHumansMaleMiddle AgedMotivationMotivational InterviewingPrisonersPrisonsReminder SystemsRNA, ViralAnti-Retroviral AgentsRNA, ViralART adherenceHIV infectionMedication adherencePrisonsTelephone pill counts

Identifiers

PMID30963321
PMCPMC6822683
OpenAlexW2937705447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.