Evidence map›Paper›PMID 30963125›Full record

ArticleHeliyon2019

The role of DOCK10 in the regulation of the transcriptome and aging.

Natalia Ruiz-Lafuente, Alfredo Minguela, Manuel Muro, Antonio Parrado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Dock10 Regulates Cardiac Function under Neurohormonal Stress.International journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natalia Ruiz-LafuenteImmunology Service, Virgen de la Arrixaca University Clinic Hospital, Biohealth Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain.
Alfredo MinguelaImmunology Service, Virgen de la Arrixaca University Clinic Hospital, Biohealth Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain.
Manuel MuroImmunology Service, Virgen de la Arrixaca University Clinic Hospital, Biohealth Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain.
Antonio ParradoImmunology Service, Virgen de la Arrixaca University Clinic Hospital, Biohealth Research Institute of Murcia (IMIB-Arrixaca), El Palmar, 30120 Murcia, Spain.
Instituto Murciano de Investigación Biosanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DOCK10, a guanine-nucleotide exchange factor (GEF) for Rac1 and Cdc42 Rho GTPases whose expression is induced by interleukin-4 (IL-4) in B cells, is involved in B cell development and function according to recent studies performed in Dock10-knockout (KO) mice. To investigate whether DOCK10 is involved in regulation of the transcriptome, changes in the gene expression profiles (GEPs) were studied by microarray in three cellular models: DOCK10 expression induced by doxycycline (dox) withdrawal in a stable inducible HeLa clone, DOCK10 expression induced by transient transfection of 293T cells, and wild type (WT)

Indexed as

BioinformaticsCell biologyImmunologyMolecular biologyPhysiology

Identifiers

PMID30963125
PMCPMC6434181
OpenAlexW2926473889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.