ArticleCommunications biology2019
Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026Review
- The multiple scales of astrocytic functional units.Nature neuroscience · 2026Review
- Heterogeneity of Astrocyte Reactivity.Annual review of neuroscience · 2025Review
- Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.Cell reports · 2025Article
- Bidirectional dysregulation of synaptic glutamate signaling after transient metabolic failure.eLife · 2024Article
- Astrocytes in selective vulnerability to neurodegenerative disease.Trends in neurosciences · 2024Review
- Pathological Interplay between Inflammation and Mitochondria Aggravates Glutamate Toxicity.International journal of molecular sciences · 2024Review
- Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation.The Journal of allergy and clinical immunology · 2024Article
- Article
- Astrocytic Glutamate Transporters and Migraine.Neurochemical research · 2023Review
- Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023Review
- Review
- Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation.The journal of headache and pain · 2022Article
- Article
- Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4.The EMBO journal · 2021Article
- The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics.Frontiers in cellular neuroscience · 2021Article
- Disruption of Glutamate Transport and Homeostasis by Acute Metabolic Stress.Frontiers in cellular neuroscience · 2021Article
- Astrocyte dysfunction increases cortical dendritic excitability and promotes cranial pain in familial migraine.Science advances · 2020Article
- Article
- Diving into new depths of astrocyte signaling.Nature neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Removal of synaptically-released glutamate by astrocytes is necessary to spatially and temporally limit neuronal activation. Recent evidence suggests that astrocytes may have specialized functions in specific circuits, but the extent and significance of such specialization are unclear. By performing direct patch-clamp recordings and two-photon glutamate imaging, we report that in the somatosensory cortex, glutamate uptake by astrocytes is slower during sustained synaptic stimulation when compared to lower stimulation frequencies. Conversely, glutamate uptake capacity is increased in the frontal cortex during higher frequency synaptic stimulation, thereby limiting extracellular buildup of glutamate and NMDA receptor activation in layer 5 pyramidal neurons. This efficient glutamate clearance relies on Na
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.