Evidence map›Paper›PMID 30963102›Full record

ArticleeNeuro

The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling.

Laura J Blair, Marangelie Criado-Marrero, Dali Zheng, Xinming Wang, Siddharth Kamath, Bryce A Nordhues, Edwin J Weeber, Chad A Dickey

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  5. Depletion ofInternational journal of molecular sciences · 2025
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  8. Knocking out Fkbp51 decreases CClCell & bioscience · 2024
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Laura J BlairDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.ORCID 0000-0002-4981-5564
Marangelie Criado-MarreroDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.ORCID 0000-0001-8307-0183
Dali ZhengDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.
Xinming WangDepartment of Pharmacology and Physiology, University of South Florida, Byrd Institute, Tampa, FL 33613.
Siddharth KamathDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.ORCID 0000-0002-9154-1157
Bryce A NordhuesDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.
Edwin J WeeberDepartment of Pharmacology and Physiology, University of South Florida, Byrd Institute, Tampa, FL 33613.ORCID 0000-0002-9800-3167
Chad A DickeyDepartment of Molecular Medicine, University of South Florida, Byrd Institute, Tampa, FL 33613.
University of South Florida · US

Funding

The Hsp90 cochaperone FKBP51 regulates tau structure and functionR01NS073899 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI Laura J Blair · 2011 to 2026
$6.9M
Modeling stress-related psychopathology through FKBP5 manipulationR01MH103848 · NIMH · UNIVERSITY OF SOUTH FLORIDA · PI BLAIR, LAURA J · 2014 to 2018
$1.9M
NIMH NIH HHS R01 MH103848NINDS NIH HHS R01 NS073899
6 · The paper itself

Abstract

Increased expression of the FK506-binding protein 5 (

Indexed as

AnimalsCognitionCognitive DysfunctionFemaleHumansLong-Term Synaptic DepressionMaleMiceMice, 129 StrainMice, TransgenicProtein TransportReceptors, AMPASpatial LearningTacrolimus Binding Protein 5Tacrolimus Binding ProteinsReceptors, AMPATacrolimus Binding Protein 5Tacrolimus Binding ProteinsAMPA receptorchaperoneFKBP5Hsp90

Identifiers

PMID30963102
PMCPMC6450497
OpenAlexW2912143836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.