ArticleLight, science & applications2019
In vivo superresolution photoacoustic computed tomography by localization of single dyed droplets.
Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The trial behind it
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Who cites it
44 citing papers in PubMed, 104 citations in OpenAlex.
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Super-resolution functional photoacoustic microscopy via label-free cell tracking.Light, science & applications · 2026Article
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Recent advancements in molecular photoacoustic tomography.JPhys photonics · 2025Review
- Non-Invasive Deep-Brain Imaging With 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).IEEE transactions on medical imaging · 2025Article
- Sound Out the Deep Clarity: Super-Resolution Photoacoustic Imaging at Depths.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Review
- Three-Dimensional Super-Resolution Passive Cavitation Mapping in Laser Lithotripsy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- Challenges and advances in two-dimensional photoacoustic computed tomography: a review.Journal of biomedical optics · 2024Review
- On the Importance of Low-Frequency Signals in Functional and Molecular Photoacoustic Computed Tomography.IEEE transactions on medical imaging · 2024Article
- Molecular imaging nanoprobes and their applications in atherosclerosis diagnosis.Theranostics · 2024Review
- Compressed single-shot 3D photoacoustic imaging with a single-element transducer.Photoacoustics · 2023Article
- On the importance of low-frequency signals in functional and molecular photoacoustic computed tomography.ArXiv · 2023Article
- Deep optoacoustic localization microangiography of ischemic stroke in mice.Nature communications · 2023Article
- Imaging of Gastrointestinal Tract Ailments.Journal of imaging · 2023Review
- Hybrid photoacoustic and fast super-resolution ultrasound imaging.Nature communications · 2023Article
- Single-shot photoacoustic imaging with single-element transducer through a spatiotemporal encoder.Journal of biomedical optics · 2023Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Photoacoustic (PA) computed tomography (PACT) is a noninvasive hybrid imaging technique that combines optical excitation and acoustic detection to realize high contrast, high resolution, and deep penetration in biological tissues. However, the spatial resolution of PACT is limited by acoustic diffraction. Here, we report in vivo superresolution PACT, which breaks the acoustic diffraction limit by localizing the centers of single dyed droplets that are flowing in blood vessels. The droplets were prepared by dissolving hydrophobic absorbing dye in oil, followed by mixing with water. The dyed droplets generate much higher-amplitude PA signals than blood and can flow smoothly in vessels; thus, they are excellent tracers for localization-based superresolution imaging. The in vivo resolution enhancement was demonstrated by continuously imaging the cortical layer of a mouse brain during droplet injection. The droplets that were flowing in the vessels were localized, and their center positions were used to construct a superresolution image that exhibits sharper features and more finely resolved vascular details. An improvement in spatial resolution by a factor of 6 has been realized in vivo by the droplet localization technique.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.