Evidence map›Paper›PMID 30962867›Full record

ArticleComputational and structural biotechnology journal2019

Risk Prediction Tool for Aggressive Tumors in Clinical T1 Stage Clear Cell Renal Cell Carcinoma Using Molecular Biomarkers.

Jee Soo Park, Hyo Jung Lee, Nam Hoon Cho, Jongchan Kim, Won Sik Jang, Ji Eun Heo, Won Sik Ham

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  16. Identification of a 5-Gene Signature Predicting Progression and Prognosis of Clear Cell Renal Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jee Soo ParkDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyo Jung LeeDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Nam Hoon ChoDepartment of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Jongchan KimDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Won Sik JangDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Ji Eun HeoDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Won Sik HamDepartment of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some early-stage clear cell renal cell carcinomas (ccRCCs) of ≤7 cm are associated with a poor clinical outcome. In this study, we investigated molecular biomarkers associated with aggressive clinical T1 stage ccRCCs of ≤7 cm, which were used to develop a risk prediction tool toward guiding the decision of treatment. Among 1069 nephrectomies performed for ccRCC of ≤7 cm conducted between January 2008 and December 2014, 177 cases with available formalin-fixed paraffin-embedded tissue were evaluated. An aggressive tumor was defined as a tumor exhibiting synchronous metastasis, recurrence, or leading to cancer-specific death. Expression levels of six genes (

Indexed as

BAP1, BRCA1 associated protein-1BiomarkerBMI, Body mass indexccRCC, Clear cell renal cell carcinomaCLIP4, CAP-Gly, cytoskeleton-associated protein-glycine rich domain-containing linker protein family member 4DNN, Deep neural networkEDTA, Ethylenediaminetetraacetic acidFFPE, Formalin-fixed paraffin-embeddedFOXC2, Forkhead box protein C2KDM5C, Lysine-specific demethylase 5CMSKCC, Memorial Sloan Kettering Cancer CenterPBRM1, Polybromo 1PBS, Phosphate-buffered salinePrediction modelqRT-PCR, Quantitative reverse transcription-polymerase chain reactionRenal cell cancerSETD2, SET domain-containing 2TNM, Tumor-node-metastasis

Identifiers

PMID30962867
PMCPMC6434066

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.