ArticleOpen access Macedonian journal of medical sciences2019
Differences in Brain-Derived Neurotrophic Factor and Matrix Metalloproteinase-9 between Appropriate Neonates between Normal Birth Weight and Intrauterine Growth Restriction.
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction.Brain pathology (Zurich, Switzerland) · 2021Article
- Vaginal Microbiota, Genital Inflammation and Extracellular Matrix Remodelling Collagenase: MMP-9 in Pregnant Women With HIV, a Potential Preterm Birth Mechanism Warranting Further Exploration.Frontiers in cellular and infection microbiology · 2021Article
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Abstract
backgroundIntrauterine Growth Restriction (IUGR) was defined as the growth of the fetus less than its normal potential growth due to genetic and environmental factors. One of the most widely believed causes of IUGR was impaired uteroplacental mechanism from mother to fetus. Furthermore, factor which was thought to affect placental growth was due to the influence of Brain-Derived Neurotrophic Factor (BDNF) and Matrix Metalloproteinase (MMP-9) which play an important role in angiogenesis.
aimThis study aims to determine differences in Brain-Derived Neurotrophic Factor (BDNF) and moderately mature Matrix Metalloproteinase (MMP-9) between normal birth weight and intrauterine growth restriction. MATERIAL AND
methodsThe study design was a cross-sectional study at four hospitals in Padang city from August 2017-January 2018. The sample of this study was umbilical cord blood of appropriate gestational age neonate with normal birth weight (31 neonates) and IUGR (31 neonates) by consecutive sampling, samples taken from mothers who meet inclusion criteria. BDNF and MMP-9 levels were analysed by ELISA. The differences between normal birth weight and IUGR test were followed by unpaired T-test.
resultsThe results showed that BDNF levels in normal neonates was 1.58 ± 0.23 ng/ml and in IUGR neonates were 1.25 ± 0.35 ng/ml (p = 0.001). MMP-9 levels in normal neonates was 1.09 ± 0.20 ng/ml and in IUGR neonates were 1.25 ± 0.35 (p = 0.03).
conclusionThe conclusion of this study was BDNF of moderately mature neonates was significantly higher in normal birth weight compared to intrauterine growth restriction, and the moderately high MMP-9 neonates were significantly higher in intrauterine growth restriction compared with normal birth weight.
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