ArticleOpen access Macedonian journal of medical sciences2019
Cell Cycle Inhibition of Ethylacetate Fraction of
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Cytotoxicity and apoptotic effects of the ethyl acetate fraction ofContemporary oncology (Poznan, Poland) · 2025Article
- Cardioprotective Effect of Hydroalcohol Extract of Andaliman (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Andaliman (Heliyon · 2023Review
- Synergistic Antibacterial Effect of Ethyl Acetate Fraction ofAdvances in pharmacological and pharmaceutical sciences · 2023Article
- Histological changes in placental rat apoptosis via FasL and cytochromeSaudi journal of biological sciences · 2021Article
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Authors and funding
5 authors.
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Abstract
backgroundThe use of medicinal plants is increasing in several decades for relief many diseases. Indonesia consists of thousands of islands with various plants and the manners of the community using plants as a treatment for every disease traditionally.
aimCytotoxic activity of ethyl acetate fraction (EAF) of
methodsThe in vitro cytotoxic activity was performed by MTT assay, and the result was expressed as the IC50 (Inhibitory Concentration), and cell cycle inhibition was investigated by flow cytometry to assess the inhibition in every phase of cell cycle, and the role of expression cyclin D1 and p53 in cell cycle inhibition were performed by immunocytochemistry.
resultsEAF was showed to have high activity with a value of IC
conclusionThe results obtained in this study provided scientific support for further investigation on compounds in
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Registered trials
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