ArticlePatient related outcome measures2019
Risk factors for poor health-related quality of life in cancer survivors with multiple chronic conditions: exploring the role of treatment burden as a mediator.
Article in Patient related outcome measures, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Unravelling the role of health literacy among individuals with multimorbidity: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Treatment burden in individuals living with and beyond cancer: A systematic review of qualitative literature.PloS one · 2023Pooled it
- Pooled it
- Pooled it
- Physical fitness and clinically assessed disease burden in long-term childhood cancer survivors-The SURfit study.Cancer · 2025Trial
- Logistic and time burdens reported by gynecologic and breast cancer survivors.BMC women's health · 2025Article
- Treatment burden in multimorbidity: an integrative review.BMC primary care · 2024Review
- The Chinese version of patient experience with treatment and self-management (PETS vs. 2.0): translation and validation in patients with multimorbidity in primary care in Hong Kong.Journal of patient-reported outcomes · 2024Article
- Cancer Survivorship Care in the United States at Facilities Accredited by the Commission on Cancer.JAMA network open · 2024Article
- Investigating psychological mechanisms linking pain severity to depression symptoms in women cancer survivors at a cancer center with a rural catchment area.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Geriatric assessment-derived deficit accumulation and patient-reported treatment burden in older adults with bladder cancer.Journal of the American Geriatrics Society · 2024Article
- Logistic burdens of cancer care: A qualitative study.PloS one · 2024Article
- A Single-Center Retrospective Evaluation of Decision-Making and Factors Motivating Hand Transplant Candidates.Progress in transplantation (Aliso Viejo, Calif.) · 2023Article
- Treatment burden in survivors of prostate and colorectal cancers: a qualitative interview study.BMJ open · 2023Article
- Clinical Multiteam System Composition and Complexity Among Newly Diagnosed Early-Stage Breast, Colorectal, and Lung Cancer Patients With Multiple Chronic Conditions: A SEER-Medicare Analysis.JCO oncology practice · 2023Article
- Time Spent Engaging in Health Care Among Patients With Left Ventricular Assist Devices.JACC. Heart failure · 2022Article
- Article
- Longitudinal trajectories of treatment burden: A prospective survey study of adults living with multiple chronic conditions in the midwestern United States.Journal of multimorbidity and comorbidity · 2022Article
- Impact of comorbidities and treatment burden on general well-being among women's cancer survivors.Journal of patient-reported outcomes · 2021Article
- Known-groups validity and responsiveness to change of the Patient Experience with Treatment and Self-management (PETS vs. 2.0): a patient-reported measure of treatment burden.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of this study was to identify risk factors for poor health-related quality of life (HRQL) in multi-morbid adult cancer survivors and explore whether perceived treatment and self-management burden mediate any of these relationships.
methodsNinety-one multi-morbid cancer survivors (median age: 65 years) completed surveys at baseline and 6 months. Demographic, psychosocial, and health care-related factors were assessed as were perceived treatment burden and general HRQL (physical and mental health). Data on medical diagnoses and cancer treatment were extracted from the medical record. Bivariate correlations screened for associations between predictors and outcomes, with significant predictors entered into multivariable linear regressions to identify unique risk factors for greater treatment burden and poorer HRQL. Follow-up regressions examined whether treatment burden mediated any of the risk factor-outcome relationships.
resultsFactors that correlated with higher baseline treatment burden included: having more diagnoses, less formal education, having seen more physicians in the past 6 months, having a mental health diagnosis, not having a set routine for one's self-management, low health literacy, low self-efficacy for self-management, and low social support (
conclusionMonitoring of psychosocial and health care-related risk factors for high treatment burden and poor HRQL can identify multi-morbid cancer survivors in need of extra support and could inform a more personalized treatment approach.
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