Evidence map›Paper›PMID 30962723›Full record

ArticleCancer management and research2019

Comparison of transcriptional profiles in human lymphocyte cells irradiated with

Ruifeng Zhang, Xuhong Dang, Zhongxin Zhang, Yayi Yuan, Yue Ren, Zhikai Duan, Yahui Zuo

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ruifeng ZhangChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Xuhong DangChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Zhongxin ZhangChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Yayi YuanChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Yue RenChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Zhikai DuanChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
Yahui ZuoChina Institute for Radiation Protection, Taiyuan, Shanxi 030006, China, yahuiz@163.com.
National Institute for Radiological Protection · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHeavy ions have contributed to tumor site-specific radiotherapy and are a major health risk for astronauts. The purpose of this study was to investigate the changes in gene expression in peripheral lymphocytes of cancer patients and astronauts exposed to MATERIALS AND

methodsA human lymphocyte cell line was irradiated with

resultsBased on the microarray assays, 1,113 genes were upregulated and 853 genes were downregulated in human lymphocyte cells irradiated with 0.1 Gy

conclusionDifferentially expressed genes between treatment and control groups at 24 hours post-irradiation increased as the radiation dose increased; upregulated genes gradually decreased and downregulated genes increased. Our data indicated that

Indexed as

12C ion beamsgene expressionhuman lymphocyte cell linemicroarray assay

Identifiers

PMID30962723
PMCPMC6434914
OpenAlexW2922993034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.