Evidence map›Paper›PMID 30962706›Full record

ArticleInternational journal of general medicine2019

Psychiatric symptoms and their association with sleep disturbances in intensive care unit survivors.

Sophia Wang, Jared W Meeker, Anthony J Perkins, Sujuan Gao, Sikandar H Khan, Ninotchka L Sigua, Shalini Manchanda, Malaz A Boustani, Babar A Khan

Open access · goldAbstract read
In one paragraph

Article in International journal of general medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. [Challenge healthcare system: spotlight on PICS].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
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  9. Article
  10. Sleep in cardiac arrest survivors.Nursing in critical care · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sophia WangDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 USA, sophwang@iupui.edu.
Jared W MeekerDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Anthony J PerkinsDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Sujuan GaoDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
Sikandar H KhanDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Ninotchka L SiguaDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Shalini ManchandaDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Malaz A BoustaniCenter for Health Innovation and Implementation Science, Clinical and Translational Science Institute, Indianapolis, IN, USA, sophwang@iupui.edu.
Babar A KhanSandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN, USA, sophwang@iupui.edu.
Indiana University School of MedicineRegenstrief Institute · USIndiana University Health · USIndiana Clinical and Translational Sciences Institute · US

Funding

Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FOROUD, TATIANA M. · 1991 to 2020
$37.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Brain Health Patient Safety Learning LaboratoryP30HS024384 · AHRQ · INDIANA UNIVERSITY INDIANAPOLIS · PI CALLAHAN, CHRISTOPHER M · 2015 to 2018
$3.8M
Decreasing Alzheimer's Disease and Related Dementias after Delirium-Exercise and Cognitive Training (DDD-ECT)R01AG055391 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.5M
Mobile Critical Care Recovery Program (m-CCRP) for Acute Respiratory Failure (ARF) SurvivorsR01HL131730 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KHAN, BABAR A · 2017 to 2021
$3.2M
Indiana University Dementia Screening Trial: The IU CHOICE StudyR01AG040220 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BOUSTANI, MALAZ · 2012 to 2016
$2.8M
AHRQ HHS P30 HS024384NCATS NIH HHS UL1 TR001108NHLBI NIH HHS R01 HL131730NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG030618NIA NIH HHS R01 AG040220NIA NIH HHS R01 AG055391
6 · The paper itself

Abstract

backgroundSleep disturbances in critically ill patients are associated with poorer long-term clinical outcomes and quality of life. Studies are needed to better characterize associations and risk factors for persistent sleep disturbances after intensive care unit (ICU) discharge. Psychiatric disorders are frequently associated with sleep disturbances, but the role of psychiatric symptoms in sleep disturbances in ICU survivors has not been well-studied.

objectiveTo examine the association between psychiatric symptoms and sleep disturbances in ICU survivors.

methods112 adult ICU survivors seen from July 2011 to August 2016 in the Critical Care Recovery Center, an ICU survivor clinic at the Eskenazi Hospital in Indianapolis, IN, USA, were assessed for sleep disturbances (insomnia, hypersomnia, difficulty with sleep onset, difficulty with sleep maintenance, and excessive daytime sleepiness) and psychiatric symptoms (trauma-related symptoms and moderate to severe depressive symptoms) 3 months after ICU discharge. A multivariate logistic regression model was performed to examine the association between psychiatric symptoms and sleep disturbances. Analyses were controlled for age, hypertension, history of depression, and respiratory failure.

resultsICU survivors with both trauma-related and depression symptoms (OR 16.66, 95% CI 2.89-96.00) and trauma-related symptoms alone (OR 4.59, 95% CI 1.11-18.88) had a higher likelihood of sleep disturbances. Depression symptoms alone were no longer significantly associated with sleep disturbances when analysis was controlled for trauma-related symptoms.

conclusionTrauma-related symptoms and trauma-related plus moderate to severe depressive symptoms were associated with a higher likelihood of sleep disturbances. Future studies are needed to determine whether psychiatric symptoms are associated with objective changes on polysomnography and actigraphy and whether adequate treatment of psychiatric symptoms can improve sleep disturbances.

Indexed as

depressionICU survivorpost-intensive care syndromepost-traumatic stress disorderpsychiatric disorderssleep disturbance

Identifiers

PMID30962706
PMCPMC6434907
OpenAlexW2922745345

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.