ArticlePharmacogenomics and personalized medicine2019
Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease.
Article in Pharmacogenomics and personalized medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A Decade of Pharmacogenetic Studies in Jordan: A Systemic Review.The pharmacogenomics journal · 2021Pooled it
- Article
- Article
- ACE gene polymorphism and susceptibility to hypertension in a Jordanian adult population.PloS one · 2024Article
- Article
- Article
- Frequency ofJournal of personalized medicine · 2022Article
- Influence ofInternational journal of medical sciences · 2021Observational
- Impact of PCSK9, WDR12, CDKN2A, and CXCL12 Polymorphisms in Jordanian Cardiovascular Patients on Warfarin Responsiveness and Sensitivity.International journal of general medicine · 2021Article
- Variants inInternational journal of general medicine · 2021Article
- Influence ofJournal of personalized medicine · 2020Article
- Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.Journal of personalized medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the influence of CYP/CYP450 2C9 ( PATIENTS AND
methodsA total of 211 cardiovascular patients who were being treated with warfarin anticoagulants and 205 healthy individuals were enrolled in this study. PCR-based methods were performed to analyze the effects of
resultsWe found that the genotypic and allelic frequencies differ significantly between patients and healthy individuals; therefore, our results suggest that this polymorphism is associated with cardiovascular disease in the Jordanian population. Moreover, during the initiation phase of therapy, 20% of warfarin-sensitive patients were homozygous for a short allele (p-VNTR-S), and 12.2% were heterozygous for this allele (p-VNTR-M/p-VNTR-S). During the stabilization phase, no significant differences were found between these groups and their genotypic frequencies. Additionally, we did not confirm any relationship between the
conclusionOur data show a significant difference between the
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Registered trials
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