Evidence map›Paper›PMID 30962686›Full record

ReviewInternational journal of nanomedicine2019

Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment.

Zhe Ma, Yuqi Fan, Yumei Wu, Dereje Kebebe, Bing Zhang, Peng Lu, Jiaxin Pi, Zhidong Liu

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Chinese herbal medicines · 2025
    Review
  7. Sorafenib-Drug Delivery Strategies in Primary Liver Cancer.Journal of functional biomaterials · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Traditional Chinese Medicine Treatment of Thyroid Cancer: A Review.International journal of general medicine · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Heliyon · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe MaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Yuqi FanInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Yumei WuEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Dereje KebebeEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Bing ZhangEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Peng LuEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Jiaxin PiEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.
Zhidong LiuEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China, pijiaxin@tjutcm.edu.cn; lonerliuzd@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of >280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.

Indexed as

Drug Delivery SystemsMedicine, Chinese TraditionalMolecular Targeted TherapyAntineoplastic AgentsDrugs, Chinese HerbalDrug Therapy, CombinationHumansNanotechnologyNeoplasmsAntineoplastic AgentsDrugs, Chinese Herbalcancercodeliverycombination therapynanotargeted drug-delivery systemTCMtumor targeting

Identifiers

PMID30962686
PMCPMC6435121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.