ArticleNature neuroscience2019
Distinct cortical-amygdala projections drive reward value encoding and retrieval.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
87 citing papers in PubMed.
- Dopamine projections to the basolateral amygdala enable reward prediction.bioRxiv : the preprint server for biology · 2026Article
- Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Memory erasure by dopamine-gated retrospective learning.bioRxiv : the preprint server for biology · 2026Article
- Pre-existing and emergent cortical neuronal assembly sequences during learning.bioRxiv : the preprint server for biology · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
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- Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice.Neuroscience bulletin · 2024Article
- A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation.bioRxiv : the preprint server for biology · 2024Article
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory.iScience · 2024Article
- Beta activity in human anterior cingulate cortex mediates reward biases.Nature communications · 2024Article
- Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors.Current biology : CB · 2024Article
- Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.Nature neuroscience · 2024Article
- A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior.Neuron · 2024Article
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Executive function, limbic circuit dynamics and repetitive and restricted behaviors in children with autism spectrum disorder.Frontiers in neuroscience · 2024Article
27 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
The value of an anticipated rewarding event is a crucial component of the decision to engage in its pursuit. But little is known of the networks responsible for encoding and retrieving this value. By using biosensors and pharmacological manipulations, we found that basolateral amygdala (BLA) glutamatergic activity tracks and mediates encoding and retrieval of the state-dependent incentive value of a palatable food reward. Projection-specific, bidirectional chemogenetic and optogenetic manipulations revealed that the orbitofrontal cortex (OFC) supports the BLA in these processes. Critically, the function of ventrolateral and medial OFC→BLA projections is doubly dissociable. Whereas lateral OFC→BLA projections are necessary and sufficient for encoding of the positive value of a reward, medial OFC→BLA projections are necessary and sufficient for retrieving this value from memory. These data reveal a new circuit for adaptive reward valuation and pursuit and provide insight into the dysfunction in these processes that characterizes myriad psychiatric diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.