ArticleNature genetics2019
Durum wheat genome highlights past domestication signatures and future improvement targets.
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Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 404 papers, 1 of them a synthesis that pooled it.
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404citing papers in PubMed, 1 pooled it
141.6field-weighted citation impact, top 1% of its field
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Who cites it
404 citing papers in PubMed, 1 synthesis or guideline pooled it, 796 citations in OpenAlex.
- Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.The plant genome · 2025Pooled it
- A Wild Emmer Wheat B3 Transcription Factor Regulates Seed Growth and Nutrient Allocation.Plant, cell & environment · 2026Article
- Distinct cadmium detoxicity response between rice cultivars carrying functional or loss-of-function OsHMA3 allele.Stress biology · 2026Article
- Fine mapping of QPm.caas-4BL.2 for adult-plant resistance to powdery mildew in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Elucidating the genetic architecture of yield components in pyramidale wheat (Molecular breeding : new strategies in plant improvement · 2026Article
- Identification of stable QTL for yield-related traits in a durum wheat Svevo × Zavitan RIL population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Effects of Traditional MoroccanFoods (Basel, Switzerland) · 2026Article
- Subtle but Significant: Intraspecific Genome Size Variation in Durum Wheat Landraces and Cultivars.Plants (Basel, Switzerland) · 2026Article
- Chromosome-scale assembly of wheat cultivar Sumai 3, a major germplasm source for Fusarium head blight resistance.The plant genome · 2026Article
- Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors.The New phytologist · 2026Article
- A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding.Nature genetics · 2026Article
- A tetraploid wheat pangenome reveals genomic variation and domestication footprints.Nature genetics · 2026Article
- Agronomic, genetic and biotechnological approaches to lower free asparagine content in cereals: state of the art and perspectives.Food chemistry: X · 2026Review
- Advances in Molecular Mechanisms Underlying Cadmium Accumulation and Detoxification in Durum Wheat (International journal of molecular sciences · 2026Review
- TWGFD: an integrative platform for tetraploid wheat gene family analysis.BMC genomics · 2026Article
- BarleyGVDB: A Comprehensive Barley Variome Database for Population Evolution and Molecular Breeding Research in Barley.Plant biotechnology journal · 2026Article
- Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement.The plant genome · 2026Review
- AMF-induced salinity tolerance in durum wheat is associated with transcriptomic modulation of the Cation/Calcium Exchanger 1 (CCX1).Mycorrhiza · 2026Article
- The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos.The New phytologist · 2026Article
- A high-quality bread wheat genome unravels the adaptive evolution of wheat end-use quality.Nature plants · 2026Article
344 more citing papers are in PubMed but not listed here.
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Authors and funding
68 authors at 20 institutions in 8 countries.
Marco MaccaferriDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-1935-3282
Neil S HarrisDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-1320-282X
Sven O TwardziokHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-0326-5704
Raj K PasamAgriculture Victoria, Agribio Centre for AgriBioscience, Bundoora, Victoria, Australia.ORCID http://orcid.org/0000-0003-0908-1882
Heidrun GundlachHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-6757-0943
Manuel SpannaglHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany.
Danara OrmanbekovaDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Thomas LuxHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-5543-1911
Verena M PradeHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany.
Sara G MilnerLeibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
Axel HimmelbachLeibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.
Martin MascherLeibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.ORCID http://orcid.org/0000-0001-6373-6013
Paolo BagnaresiCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.ORCID http://orcid.org/0000-0001-8466-4805
Primetta FaccioliCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.ORCID http://orcid.org/0000-0002-8019-3409
Paolo CozziNational Research Council-Institute of Agricultural Biology and Biotechnology, Milano, Italy.
Massimiliano LauriaNational Research Council-Institute of Agricultural Biology and Biotechnology, Milano, Italy.
Barbara LazzariNational Research Council-Institute of Agricultural Biology and Biotechnology, Milano, Italy.ORCID http://orcid.org/0000-0002-9558-914X
Alessandra StellaNational Research Council-Institute of Agricultural Biology and Biotechnology, Milano, Italy.
Andrea ManconiNational Research Council-Institute of Biomedical Technologies, Segrate, Italy.ORCID http://orcid.org/0000-0002-1287-2768
Matteo GnocchiNational Research Council-Institute of Biomedical Technologies, Segrate, Italy.
Marco MoscatelliNational Research Council-Institute of Biomedical Technologies, Segrate, Italy.
Raz AvniSchool of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0002-0801-5093
Jasline DeekSchool of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel.
Sezgi BiyikliogluMontana State University, Bozeman, MT, USA.
Elisabetta FrascaroliDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-1699-2764
Simona CornetiDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Silvio SalviDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Gabriella SonnanteNational Research Council-Institute of Biosciences and Bioresources, Bari, Italy.
Francesca DesiderioCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.
Caterina MarèCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.
Cristina CrosattiCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.ORCID http://orcid.org/0000-0001-7265-4431
Erica MicaCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.ORCID http://orcid.org/0000-0002-3536-4248
Hakan ÖzkanÇukurova University, Faculty of Agriculture, Department of Field Crops, Adana, Turkey.ORCID http://orcid.org/0000-0003-3530-2626
Benjamin KilianGlobal Crop Diversity Trust, Bonn, Germany.
Pasquale De VitaCREA-Research Centre for Cereal and Industrial Crops, Foggia, Italy.ORCID http://orcid.org/0000-0002-9573-0510
Daniela MaroneCREA-Research Centre for Cereal and Industrial Crops, Foggia, Italy.
Reem JoukhadarAgriculture Victoria, Agribio Centre for AgriBioscience, Bundoora, Victoria, Australia.
Elisabetta MazzucotelliCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy.ORCID http://orcid.org/0000-0002-8578-6502
Domenica NigroDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-7289-1143
Agata GadaletaDepartment of Agricultural and Environmental Science, University of Bari Aldo Moro, Bari, Italy.ORCID http://orcid.org/0000-0002-6312-249X
Shiaoman ChaoUnited States Department of Agriculture, Agricultural Research Service, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.
Justin D FarisUnited States Department of Agriculture, Agricultural Research Service, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.ORCID http://orcid.org/0000-0002-9653-3287
Arthur T O MeloDepartment of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, USA.
Mike PumphreyDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, USA.
Nicola PecchioniCREA-Research Centre for Cereal and Industrial Crops, Foggia, Italy.
Luciano MilanesiNational Research Council-Institute of Biomedical Technologies, Segrate, Italy.
Krystalee WiebeCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Jennifer EnsCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Ron P MacLachlanCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
John M ClarkeCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Andrew G SharpeGlobal Institute for Food Security, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Chu Shin KohGlobal Institute for Food Security, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Kevin Y H LiangDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Gregory J TaylorDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Ron KnoxSwift Current Research and Development Centre, Agriculture and Agri-Food Canada, Swift Current, Saskatchewan, Canada.ORCID http://orcid.org/0000-0002-2030-3899
Hikmet BudakMontana State University, Bozeman, MT, USA.ORCID http://orcid.org/0000-0002-2556-2478
Anna M MastrangeloCREA-Research Centre for Cereal and Industrial Crops, Foggia, Italy.ORCID http://orcid.org/0000-0002-3618-0301
Steven S XuUnited States Department of Agriculture, Agricultural Research Service, Edward T. Schafer Agricultural Research Center, Fargo, ND, USA.ORCID http://orcid.org/0000-0001-7000-2034
Nils SteinLeibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany.ORCID http://orcid.org/0000-0003-3011-8731
Iago HaleDepartment of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, USA.ORCID http://orcid.org/0000-0002-8558-7861
Assaf DistelfeldSchool of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel.
Matthew J HaydenAgriculture Victoria, Agribio Centre for AgriBioscience, Bundoora, Victoria, Australia.ORCID http://orcid.org/0000-0003-3117-5500
Roberto TuberosaDepartment of Agricultural and Food Sciences, University of Bologna, Bologna, Italy.
Sean WalkowiakCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Klaus F X MayerHelmholtz Zentrum München, Plant Genome and Systems Biology, Neuherberg, Germany. k.mayer@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0001-6484-1077
Aldo CeriottiNational Research Council-Institute of Agricultural Biology and Biotechnology, Milano, Italy. ceriotti@ibba.cnr.it.ORCID http://orcid.org/0000-0002-8230-8863
Curtis J PozniakCrop Development Centre and Department of Plant Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. curtis.pozniak@usask.ca.ORCID http://orcid.org/0000-0002-7536-3856
Luigi CattivelliCREA-Research Centre for Genomics and Bioinformatics, Fiorenzuola d'Arda, Italy. luigi.cattivelli@crea.gov.it.ORCID http://orcid.org/0000-0002-6067-4600
University of Saskatchewan · CAHelmholtz Zentrum München · DEInstitut thématique Génétique, génomique et bioinformatique · FRCereal Research Centre · ITInstitute of Agricultural Biology and Biotechnology · ITInstitute of Biomedical Technologies · ITUniversity of Bologna · ITAgricultural Research Service · USLeibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) · DETel Aviv University · ILUniversity of Alberta · CALa Trobe University · AUMontana State University · USUniversity of Bari Aldo Moro · ITUniversity of New Hampshire · USAgriculture and Agri-Food Canada · CAAgriculture Victoria · AUCukurova University · TRForestry Research Centre · ITGerman Centre for Integrative Biodiversity Research · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The domestication of wild emmer wheat led to the selection of modern durum wheat, grown mainly for pasta production. We describe the 10.45 gigabase (Gb) assembly of the genome of durum wheat cultivar Svevo. The assembly enabled genome-wide genetic diversity analyses revealing the changes imposed by thousands of years of empirical selection and breeding. Regions exhibiting strong signatures of genetic divergence associated with domestication and breeding were widespread in the genome with several major diversity losses in the pericentromeric regions. A locus on chromosome 5B carries a gene encoding a metal transporter (TdHMA3-B1) with a non-functional variant causing high accumulation of cadmium in grain. The high-cadmium allele, widespread among durum cultivars but undetected in wild emmer accessions, increased in frequency from domesticated emmer to modern durum wheat. The rapid cloning of TdHMA3-B1 rescues a wild beneficial allele and demonstrates the practical use of the Svevo genome for wheat improvement.
Indexed as
Adenosine TriphosphatasesCadmiumChromosomes, PlantDomesticationGenetic VariationGenome, PlantPhylogenyPlant BreedingPlant ProteinsPolymorphism, Single NucleotideQuantitative Trait LociSelection, GeneticSyntenyTetraploidyTriticumAdenosine TriphosphatasesCadmiumcadmium translocating ATPasePlant Proteins
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