Evidence map›Paper›PMID 30962546›Full record

ArticleNature nanotechnology2019

Soft biomimetic nanoconfinement promotes amorphous water over ice.

Livia Salvati Manni, Salvatore Assenza, Michael Duss, Jijo J Vallooran, Fanni Juranyi, Simon Jurt, Oliver Zerbe, Ehud M Landau, Raffaele Mezzenga

Abstract read
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In one paragraph

Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Phase Behavior of the Phytantriol/C16EO10 System under Controlled Hydration Conditions.Langmuir : the ACS journal of surfaces and colloids · 2026
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  7. Characterization of Water Structure and Phase Behavior within Metal-Organic Nanotubes.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Livia Salvati ManniDepartment of Chemistry, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-8870-2477
Salvatore AssenzaDepartment of Health Sciences & Technology, ETH Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-9983-8927
Michael DussDepartment of Chemistry, University of Zürich, Zürich, Switzerland.
Jijo J VallooranDepartment of Chemistry, University of Zürich, Zürich, Switzerland.
Fanni JuranyiLaboratory for Neutron Scattering and Imaging, Paul Scherrer Institut, Villigen, Switzerland.ORCID http://orcid.org/0000-0002-3223-072X
Simon JurtDepartment of Chemistry, University of Zürich, Zürich, Switzerland.
Oliver ZerbeDepartment of Chemistry, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-0475-438X
Ehud M LandauDepartment of Chemistry, University of Zürich, Zürich, Switzerland. ehud.landau@chem.uzh.ch.ORCID http://orcid.org/0000-0001-7133-5084
Raffaele MezzengaDepartment of Health Sciences & Technology, ETH Zürich, Zürich, Switzerland. raffaele.mezzenga@hest.ethz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water is a ubiquitous liquid with unique physicochemical properties, whose nature has shaped our planet and life as we know it. Water in restricted geometries has different properties than in bulk. Confinement can prevent low-temperature crystallization of the molecules into a hexagonal structure and thus create a state of amorphous water. To understand the survival of life at subzero temperatures, it is essential to elucidate this behaviour in the presence of nanoconfining lipidic membranes. Here we introduce a family of synthetic lipids with designed cyclopropyl modifications in the hydrophobic chains that exhibit unique liquid-crystalline behaviour at low temperature, which enables the maintenance of amorphous water down to ~10 K due to nanoconfinement. The combination of experiments and molecular dynamics simulations unveils a complex lipid-water phase diagram in which bicontinuous cubic and lamellar liquid crystalline phases that contain subzero liquid, glassy or ice water emerge as a competition between the two components, each pushing towards its thermodynamically favoured state.

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.