Evidence map›Paper›PMID 30962532›Full record

ArticleScientific reports2019

Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F

Sung Hye Kim, Lucia Riaposova, Hauwa Ahmed, Oliver Pohl, André Chollet, Jean-Pierre Gotteland, Aylin Hanyaloglu, Phillip R Bennett, Vasso Terzidou

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. The hormonal control of parturition.Physiological reviews · 2024
    Review
  8. Near-infrared nanosensors enable optical imaging of oxytocin with selectivity over vasopressin in acute mouse brain slices.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. A historical narrative review through the field of tocolysis in threatened preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Preterm Birth Therapies to Target Inflammation.Journal of clinical pharmacology · 2022
    Article
  17. High Plasma Oxytocin Levels in Men With Hypersexual Disorder.The Journal of clinical endocrinology and metabolism · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sung Hye KimImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.
Lucia RiaposovaImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.
Hauwa AhmedImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.
Oliver PohlObsEva SA, R&D, Chemin des Aulx 12, CH-1228, Plan-les-Ouates, Geneva, Switzerland.
André CholletObsEva SA, R&D, Chemin des Aulx 12, CH-1228, Plan-les-Ouates, Geneva, Switzerland.
Jean-Pierre GottelandObsEva SA, R&D, Chemin des Aulx 12, CH-1228, Plan-les-Ouates, Geneva, Switzerland.
Aylin HanyalogluImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.ORCID http://orcid.org/0000-0003-4206-737X
Phillip R BennettImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK.
Vasso TerzidouImperial College London, Parturition Research Group, IRDB, Du Cane Road, London, W12 0NN, UK. v.terzidou@imperial.ac.uk.ORCID http://orcid.org/0000-0002-7579-4947
Imperial College London · GBObsEva (Switzerland) · CHRED Consulting (Norway) · NO

Funding

Department of Health P45272
6 · The paper itself

Abstract

Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Similar to OT, prostaglandins (PGs) play key roles in myometrial contractility and cervical ripening. Inhibition of PG synthesis/activity is used to delay preterm birth. Thus, targeting the PG pathway in combination with an OTR-A may be an effective strategy for delaying preterm delivery. In this study, we examined the effects of atosiban and nolasiban on PGF

Indexed as

Muscle ContractionAdultAnti-Inflammatory AgentsCalciumCells, CulturedCyclooxygenase 2DinoprostFemaleHumansMAP Kinase Signaling SystemMyometriumNF-kappa BOximesOxytocinPregnancyPyrrolidinesAnti-Inflammatory AgentsatosibanCalciumCyclooxygenase 2DinoprostNF-kappa BnolasibanOximesOxytocinPyrrolidinesTocolytic AgentsVasotocin

Identifiers

PMID30962532
PMCPMC6453954
OpenAlexW2925603135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.