ArticleNature plants2019
The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling.
Article in Nature plants, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Dry side of the core: a meta-analysis addressing the original nature of the ABA signalosome at the onset of seed imbibition.Frontiers in plant science · 2023Pooled it
- Stomatal cytokinesis defective2-dependent endocytic vesicular trafficking of abscisic acid.iScience · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- ESCRTs in plant abiotic stresses.Essays in biochemistry · 2025Review
- QTL mapping and candidate gene identification of the full flowering date trait in olive trees (Olea Europaea L.).BMC plant biology · 2025Article
- OsNRT1.1B-OsCNGC14/16-CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The ESCRT component FYVE4 modulates salt-stress response by strengthening the SOS1-SOS2 interaction in Arabidopsis.Plant communications · 2025Article
- Identification and development of KASP markers for genetic loci controlling plant height in bread wheat and evaluation their effects using near isogenic lines.BMC plant biology · 2025Article
- Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells.Science advances · 2025Article
- The green ESCRTs: Newly defined roles for ESCRT proteins in plants.The Journal of biological chemistry · 2025Review
- SOS2 phosphorylates FREE1 to regulate multi-vesicular body trafficking and vacuolar dynamics under salt stress.The Plant cell · 2025Article
- The transcriptional regulation of ArabidopsisPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Stress granules sequester autophagy proteins to facilitate plant recovery from heat stress.Nature communications · 2024Article
- Hyperosmolarity-induced suppression of group B1 Raf-like protein kinases modulates drought-growth trade-off inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- The U-box E3 ubiquitin ligase PUB35 negatively regulates ABA signaling through AFP1-mediated degradation of ABI5.The Plant cell · 2024Article
- N-glycosylation of SnRK2s affects NADPH maintenance in peroxisomes during prolonged ABA signalling.Nature communications · 2024Article
- PINOID-centered genetic interactions mediate auxin action in cotyledon formation.Plant direct · 2024Review
- Bioinformatic Analysis for Identifying Transcription Factors Involved in Protein Secretion and Vacuole Formation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Identification of Neighboring Proteins of Endosomal Regulators by Using TurboID-Based Proximity Labeling.Methods in molecular biology (Clifton, N.J.) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endosomal sorting complex required for transport (ESCRT) machinery has been well documented for its function in endosomal sorting in eukaryotes. Here, we demonstrate an up-to-now unknown and non-endosomal function of the ESCRT component in plants. We show that FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING 1 (FREE1), a recently identified plant-specific ESCRT component essential for multivesicular body biogenesis, plays additional functions in the nucleus in transcriptional inhibition of abscisic acid (ABA) signalling. Following ABA treatment, SNF1-related protein kinase 2 (SnRK2) kinases phosphorylate FREE1, a step requisite for ABA-induced FREE1 nuclear import. In the nucleus, FREE1 interacts with the basic leucine zipper transcription factors ABA-RESPONSIVE ELEMENTS BINDING FACTOR4 and ABA-INSENSITIVE5 to reduce their binding to the cis-regulatory sequences of downstream genes. Collectively, our study demonstrates the crosstalk between endomembrane trafficking and ABA signalling at the transcriptional level and highlights the moonlighting properties of the plant ESCRT subunit FREE1, which has evolved unique non-endosomal functions in the nucleus besides its roles in membrane trafficking in the cytoplasm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.