Evidence map›Paper›PMID 30962495›Full record

ArticleScientific reports2019

On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity.

Azzurra Stefanucci, Wei Lei, Stefano Pieretti, Ettore Novellino, Marilisa Pia Dimmito, Francesca Marzoli, John M Streicher, Adriano Mollica

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Myxarylin: TotalJournal of the American Chemical Society · 2026
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  2. LC-MS Based Analysis and Biological Properties ofAntioxidants (Basel, Switzerland) · 2021
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  3. Article
  4. Article
  5. A Survey of Molecular Imaging of Opioid Receptors.Molecules (Basel, Switzerland) · 2019
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Azzurra StefanucciDipartimento di Farmacia, Università di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100, Chieti, Italy.
Wei LeiDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Stefano PierettiIstituto Superiore di Sanità, Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei farmaci, Viale Regina Elena 299, 00161, Rome, Italy.
Ettore NovellinoDipartimento di Farmacia, Università di Napoli "Federico II", Via D. Montesano 49, 80131, Naples, Italy.
Marilisa Pia DimmitoDipartimento di Farmacia, Università di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100, Chieti, Italy.
Francesca MarzoliIstituto Superiore di Sanità, Centro Nazionale Ricerca e Valutazione Preclinica e Clinica dei farmaci, Viale Regina Elena 299, 00161, Rome, Italy.
John M StreicherDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Adriano MollicaDipartimento di Farmacia, Università di Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, 66100, Chieti, Italy. a.mollica@unich.it.
University of Chieti-Pescara · ITIstituto Superiore di Sanità · ITUniversity of Arizona · USUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we report the chemical synthesis of two DPDPE analogues 7a (NOVA1) and 7b (NOVA2). This entailed the solid-phase synthesis of two enkephalin precursor chains followed by a Cu

Indexed as

AnalgesicsAnimalsCHO CellsClick ChemistryCricetinaeCricetulusCycloaddition ReactionEnkephalin, D-Penicillamine (2,5)-HumansMaleMiceProtein BindingReceptors, Opioid, muAnalgesicsEnkephalin, D-Penicillamine (2,5)-Receptors, Opioid, mu

Identifiers

PMID30962495
PMCPMC6453917
OpenAlexW2931890605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.