ArticleScientific reports2019
Brain-transportable dipeptides across the blood-brain barrier in mice.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis.Fluids and barriers of the CNS · 2026Article
- Oral Administration of the Adiponectin Receptor 1 Agonistic Dipeptide Tyr-Pro Prevents Hyperglycemia in Spontaneously Diabetic Torii Rats.ACS omega · 2025Article
- Preventive effect of Tyr-Pro, a blood-brain barrier transportable dipeptide, on memory impairment in SAMP8 mice.NPJ science of food · 2024Article
- A Lupin (International journal of molecular sciences · 2024Article
- Impact of Peptide Transport and Memory Function in the Brain.Nutrients · 2024Review
- Ile-Pro-Pro attenuates sympathetic activity and hypertension.Journal of physiology and biochemistry · 2024Article
- Chronic ingestion of soy peptide supplementation reduces aggressive behavior and abnormal fear memory caused by juvenile social isolation.Scientific reports · 2024Article
- Combined Widely Targeted Metabolomic, Transcriptomic, and Spatial Metabolomic Analysis Reveals the Potential Mechanism of Coloration and Fruit Quality Formation inFoods (Basel, Switzerland) · 2024Article
- Food-derived Peptides as Promising Neuroprotective Agents: Mechanism and Therapeutic Potential.Current topics in medicinal chemistry · 2024Review
- A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration.Scientific reports · 2023Article
- Improvement of memory function via a combination of exercise and soy peptide supplementation in community-dwelling older adults: A randomized controlled trial.Contemporary clinical trials communications · 2022Article
- Modelling the Human Blood-Brain Barrier in Huntington Disease.International journal of molecular sciences · 2022Article
- Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review.Marine drugs · 2022Review
- The glycine-containing dipeptide leucine-glycine raises accumbal dopamine levels in a subpopulation of rats presenting a lower endogenous dopamine tone.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Article
- Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle.Metabolites · 2021Article
- Evaluation of anticancer activity in vitro of a stable copper(I) complex with phosphine-peptide conjugate.Scientific reports · 2021Article
- Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.ACS medicinal chemistry letters · 2021Article
- A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer's Disease Model Mice.Frontiers in pharmacology · 2021Article
- Unnarmicin D, an Anti-inflammatory Cyanobacterial Metabolite with δ and μ Opioid Binding Activity Discovered via a Pipeline Approach Designed to Target Neurotherapeutics.ACS chemical neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apart from nutrients required for the brain, there has been no report that naturally occurring peptides can cross the blood-brain barrier (BBB). The aim of this study was to identify the BBB-transportable peptides using in situ mouse perfusion experiments. Based on the structural features of Gly-N-methylated Gly (Gly-Sar), a reported BBB-transportable compound, 18 dipeptides were synthesized, and were perfused in the mouse brain for two minutes. Among the synthesized dipeptides, Gly-Sar, Gly-Pro, and Tyr-Pro were transported across the BBB with K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.