Evidence map›Paper›PMID 30962431›Full record

ArticleNature communications2019

Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation.

Jun Zheng, Rong Fan, Huiqiong Wu, Honghui Yao, Yujie Yan, Jiamiao Liu, Lu Ran, Zhifang Sun, Lunzhao Yi, Li Dang and 6 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 379 citations in OpenAlex.

  1. Review
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  7. Advances in carrier-free nanodrug delivery systems.Drug delivery and translational research · 2026
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Jun ZhengKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China.
Rong FanInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University, 410008, Changsha, China.
Huiqiong WuKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China.
Honghui YaoXiangya School of Medicine, Central South University, 410013, Changsha, China.
Yujie YanXiangya School of Medicine, Central South University, 410013, Changsha, China.
Jiamiao LiuXiangya School of Medicine, Central South University, 410013, Changsha, China.
Lu RanYunnan Food Safety Research Institute, Kunming University of Science and Technology, 650500, Kunming, China.
Zhifang SunKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China.
Lunzhao YiYunnan Food Safety Research Institute, Kunming University of Science and Technology, 650500, Kunming, China.
Li DangDepartment of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 515063, Shantou, China.
Pingping GanDepartment of Oncology, Xiangya Hospital, Central South University, 410008, Changsha, China.
Piao ZhengCollege of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, 410208, Changsha, China.
Tilong YangSouthern University of Science and Technology, 518055, Shenzhen, China.
Yi ZhangKey Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, 410083, Changsha, China. yzhangcsu@csu.edu.cn.ORCID http://orcid.org/0000-0002-8452-9694
Tao TangInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University, 410008, Changsha, China. tangtaotay@csu.edu.cn.
Yang WangInstitute of Integrative Medicine, Key Laboratory of Hunan Province for Liver Manifestation of Traditional Chinese Medicine, Xiangya Hospital, Central South University, 410008, Changsha, China. wangyang_xy87@csu.edu.cn.ORCID http://orcid.org/0000-0003-0447-3107
Central South University · CNKunming University of Science and Technology · CNHunan University of Traditional Chinese Medicine · CNShantou University · CNSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.

Indexed as

AnimalsAnthraquinonesAnti-Inflammatory AgentsCell LineDelayed-Action PreparationsDrug CarriersDrug Evaluation, PreclinicalDrug LiberationHydrogelsInflammationLipopolysaccharidesMiceMicrogliaMicroscopy, Electron, ScanningNanofibersNF-KappaB Inhibitor alphaAnthraquinonesAnti-Inflammatory AgentsDelayed-Action PreparationsDrug CarriersHydrogelsLipopolysaccharidesNF-KappaB Inhibitor alphaNfkbia protein, mousePhytochemicalsRela protein, mouserheinTlr4 protein, mouseToll-Like Receptor 4Transcription Factor RelA

Identifiers

PMID30962431
PMCPMC6453967
OpenAlexW2939058834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.