ArticleProceedings of the National Academy of Sciences of the United States of America2019
Synergy of topoisomerase and structural-maintenance-of-chromosomes proteins creates a universal pathway to simplify genome topology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions.Nature communications · 2026Article
- Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks.Nature communications · 2026Article
- Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae.The EMBO journal · 2026Article
- Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA.Nucleic acids research · 2026Article
- Motorized chromosome models of mitotic chromosome folding.Nature communications · 2025Article
- Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search.Nucleic acids research · 2025Article
- Mitotic genome folding.The Journal of cell biology · 2025Review
- Topologically-crosslinked hydrogels based on γ-cyclodextrins.Communications chemistry · 2025Review
- SRBD1 facilitates chromosome segregation by promoting topoisomerase IIα localization to mitotic chromosomes.Nature communications · 2025Article
- Motor domain of condensin and step formation in extruding loop of DNA.Journal of biological physics · 2024Article
- Review
- Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent.bioRxiv : the preprint server for biology · 2024Article
- DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity.Nucleic acids research · 2024Article
- Dynamics of chromosome organization in a minimal bacterial cell.Frontiers in cell and developmental biology · 2023Article
- Topoisomerases I and II facilitate condensin DC translocation to organize and repress X chromosomes in C. elegans.Molecular cell · 2022Article
- Topological gelation of reconnecting polymers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Regulation of the mitotic chromosome folding machines.The Biochemical journal · 2022Article
- Mechanisms of Chromosome Folding and Nuclear Organization: Their Interplay and Open Questions.Cold Spring Harbor perspectives in biology · 2022Review
- Shaping the genome via lengthwise compaction, phase separation, and lamina adhesion.Nucleic acids research · 2022Article
- Circuit topology analysis of cellular genome reveals signature motifs, conformational heterogeneity, and scaling.iScience · 2022Article
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3 authors.
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Abstract
Topological entanglements severely interfere with important biological processes. For this reason, genomes must be kept unknotted and unlinked during most of a cell cycle. Type II topoisomerase (TopoII) enzymes play an important role in this process but the precise mechanisms yielding systematic disentanglement of DNA in vivo are not clear. Here we report computational evidence that structural-maintenance-of-chromosomes (SMC) proteins-such as cohesins and condensins-can cooperate with TopoII to establish a synergistic mechanism to resolve topological entanglements. SMC-driven loop extrusion (or diffusion) induces the spatial localization of essential crossings, in turn catalyzing the simplification of knots and links by TopoII enzymes even in crowded and confined conditions. The mechanism we uncover is universal in that it does not qualitatively depend on the specific substrate, whether DNA or chromatin, or on SMC processivity; we thus argue that this synergy may be at work across organisms and throughout the cell cycle.
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