Evidence map›Paper›PMID 30962385›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Structural insights into unique features of the human mitochondrial ribosome recycling.

Ravi K Koripella, Manjuli R Sharma, Paul Risteff, Pooja Keshavan, Rajendra K Agrawal

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Translation in Mitochondrial Ribosomes.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  9. Evolution: Mitochondrial Ribosomes Across Species.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. The Diseased Mitoribosome.FEBS letters · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ravi K KoripellaDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509.
Manjuli R SharmaDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509.
Paul RisteffDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509.
Pooja KeshavanDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509.
Rajendra K AgrawalDivision of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509; Rajendra.Agrawal@health.ny.gov.

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Structural Aspects of Protein Synthesis in the Mammalian MitochondriaR01GM061576 · NIGMS · WADSWORTH CENTER · PI AGRAWAL, RAJENDRA K · 2001 to 2018
$6.4M
NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM061576
6 · The paper itself

Abstract

Mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing proteins that are essential for oxidative phosphorylation (ATP generation). Despite their common ancestry with bacteria, the composition and structure of the human mitoribosome and its translational factors are significantly different from those of their bacterial counterparts. The mammalian mitoribosome recycling factor (RRF

Indexed as

Mitochondrial RibosomesRibosomal ProteinsCryoelectron MicroscopyGTP PhosphohydrolasesHumansModels, MolecularPeptidyl TransferasesRNA, RibosomalRNA, TransferGTP PhosphohydrolasesPeptidyl Transferasesribosomal protein L16Ribosomal Proteinsribosome releasing factorRNA, RibosomalRNA, Transfer55S–RRFmt complexcryo-EM structurehuman mitochondrial RRFmito-specific interactionsmito-specific sequence

Identifiers

PMID30962385
PMCPMC6486771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.