Evidence map›Paper›PMID 30962335›Full record

ArticleAntimicrobial agents and chemotherapy2019

Preclinical Development of Inhalable d-Cycloserine and Ethionamide To Overcome Pharmacokinetic Interaction and Enhance Efficacy against

Rajeev Ranjan, Ashish Srivastava, Reena Bharti, Trisha Roy, Sonia Verma, Lipika Ray, Amit Misra

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rajeev RanjanCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Ashish SrivastavaCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Reena BhartiCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Trisha RoyCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Sonia VermaCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Lipika RayCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India.
Amit MisraCSIR-Central Drug Research Institute, Janakipuram Extension, Lucknow, India amit_misra@cdri.res.in.ORCID 0000-0001-5503-0694
Central Drug Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the pharmacokinetics and efficacy of a combination of d-cycloserine (DCS) and ethionamide (ETO) via oral and inhalation routes in mice. The plasma half-life (

Indexed as

Administration, InhalationAdministration, OralAnimalsAntitubercular AgentsCycloserineDrug Resistance, BacterialEthionamideLungMiceMycobacterium tuberculosisTuberculosis, PulmonaryAntitubercular AgentsCycloserineEthionamided-cycloserinedrug deliveryethionamidemultidrug resistancepharmacokineticstuberculosis

Identifiers

PMID30962335
PMCPMC6535545
OpenAlexW2940229408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.