Evidence map›Paper›PMID 30962286›Full record

ArticleThe Journal of biological chemistry2019

AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs.

Incheol Ryu, Yoon Ki Kim

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Incheol RyuFrom the Creative Research Initiatives Center for Molecular Biology of Translation and Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea ryu.incheol@gmail.com.
Yoon Ki KimFrom the Creative Research Initiatives Center for Molecular Biology of Translation and Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea yk-kim@korea.ac.kr.ORCID 0000-0003-1303-072X
Korea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication-dependent histone (RDH) mRNAs have a nonpolyadenylated 3'-UTR that ends in a highly conserved stem-loop structure. Nonetheless, a subset of RDH mRNAs has a poly(A) tail under physiological conditions. The biological meaning of poly(A)-containing (+) RDH mRNAs and details of their biosynthesis remain elusive. Here, using HeLa cells and Western blotting, qRT-PCR, and biotinylated RNA pulldown assays, we show that poly(A)

Indexed as

AU Rich ElementsHeLa CellsHistonesHumansRNA, MessengerRNA StabilityTATA-Binding Protein Associated FactorsBRF1 protein, humanHistonesRNA, MessengerTATA-Binding Protein Associated FactorsARE-mediated mRNA decaybutyrate response factor 1 (BRF1)ELAV like RNA binding protein 1 (ELAVL1)histone mRNA biogenesisHu antigen R (HuR)mRNA stabilitypolyadenylationposttranscriptional regulationreplication-dependent histone mRNARNARNA degradationRNA metabolismRNA-protein interactionRNA turnoverZFP36 ring finger protein like 1 (ZFP36L1)

Identifiers

PMID30962286
PMCPMC6514627
OpenAlexW2939928936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.