ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021Pooled it
- Deciphering the circadian signature in acute myeloid leukemia: NPAS2 downregulation as a master predictive feature.Blood research · 2026Article
- Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.Nature communications · 2026Article
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- A Pocket Guide for the Experimenter Studying Daily Rhythms in Memory-Related Behavior.Current protocols · 2025Article
- Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance to Psychiatric Disease.Biological psychiatry · 2024Review
- The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens.Molecular psychiatry · 2024Article
- Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens.Molecular psychiatry · 2024Article
- Adolescent circadian rhythm disruption increases reward and risk-taking.Frontiers in neuroscience · 2024Article
- Review
- Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome.Journal of proteome research · 2023Article
- Emotionally clocked out: cell-type specific regulation of mood and anxiety by the circadian clock system in the brain.Frontiers in molecular neuroscience · 2023Review
- Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells.GigaScience · 2022Article
- A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice.Psychopharmacology · 2022Article
- Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia.Genes, brain, and behavior · 2022Article
- Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior.Biological psychiatry · 2022Article
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Circadian transcription factor NPAS2 and the NADThe European journal of neuroscience · 2022Article
- The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders.Frontiers in physiology · 2022Review
- Neuroplasticity and Multilevel System of Connections Determine the Integrative Role of Nucleus Accumbens in the Brain Reward System.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Puja K ParekhTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.
Ryan W LoganTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0001-8579-015X
Kyle D KetchesinTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0002-2861-5811
Darius Becker-KrailTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0002-1751-0598
Micah A SheltonTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.
Mariah A HildebrandTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0003-4159-4047
Kelly BarkoTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0002-8029-6272
Yanhua H HuangTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and.ORCID 0000-0003-1770-0196
Colleen A McClungTranslational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, and mcclungca@upmc.edu.ORCID 0000-0003-4719-6197
University of Pittsburgh · US
Funding
Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI J. DAVID JENTSCH · 2016 to 2026
$26.2MTraining for Transformative Discovery in PsychiatryT32MH016804 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2025
$6.2MRole of NPAS2 in the nucleus accumbens in drug addictionR01DA039865 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2015 to 2024
$3.9MDopamine Signaling and Synaptic Plasticity in the Nucleus AccumbensR01MH101147 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2014 to 2018
$1.9MTraining Program in the Neurobiology of Substance Use and AbuseT32DA031111 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORBES, ERIKA E, GRACE, ANTHONY A · 2011 to 2015
$1.8MSynaptic Reorganization in Drug AddictionR01DA035805 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2014 to 2018
$1.7MGenerating novel mouse tools to investigate brain region and cell-type specific circadian molecular mechanisms of reward and motivationR33DA041872 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOGAN, RYAN W, MCCLUNG, COLLEEN A · 2018 to 2020
$1.1MThe role of the circadian transcription factor NPAS2 in the nucleus accumbens to regulate cocaine rewardK01DA038654 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOGAN, RYAN W · 2015 to 2018
$626kTrans-Synaptic Luminescent Opsins:Developing pathway-, cell type-, and synapse-specific optogeneticsR21DA047108 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2018 to 2019
$391kGenerating novel mouse tools to investigate brain region and cell-type specific circadian molecular mechanisms of reward and motivationR21DA041872 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOGAN, RYAN W, MCCLUNG, COLLEEN A · 2016 to 2017
$379kNIDA NIH HHS K01 DA038654NIDA NIH HHS P50 DA039841NIDA NIH HHS R01 DA035805NIDA NIH HHS R01 DA039865NIDA NIH HHS R21 DA041872NIDA NIH HHS R21 DA047108NIDA NIH HHS R33 DA041872NIDA NIH HHS T32 DA031111NIMH NIH HHS R01 MH101147NIMH NIH HHS T32 MH016804
Abstract
The circadian transcription factor neuronal PAS domain 2 (NPAS2) is linked to psychiatric disorders associated with altered reward sensitivity. The expression of
Indexed as
SynapsesAnimalsBasic Helix-Loop-Helix ProteinsCocaineCocaine-Related DisordersFemaleGlutamic AcidMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeuronal PlasticityNucleus AccumbensRewardSynaptic TransmissionBasic Helix-Loop-Helix ProteinsCocaineGlutamic AcidNerve Tissue ProteinsNpas2 protein, mousecircadian rhythmscocaineglutamatergicnucleus accumbenstranscription factor
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.