Evidence map›Paper›PMID 30961791›Full record

ArticleDeutsches Arzteblatt international2019

Estimation of the Number of People With Opioid Addiction in Germany.

Ludwig Kraus, Nicki-Nils Seitz, Bernd Schulte, Peter Cremer-Schaeffer, Barbara Braun, Uwe Verthein, Tim Pfeiffer-Gerschel

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In one paragraph

Article in Deutsches Arzteblatt international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  6. Pre-injury narcotic drug use in isolated severe traumatic brain injury: effect on outcomes.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
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  19. [The US opioid epidemic is threatening Germany].Schmerz (Berlin, Germany) · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Ludwig KrausIFT Institut für Therapieforschung, München; Department for Public Health Sciences, Stockholm University, Stockholm, Sweden and Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary; Centre of Interdisciplinary Addiction Research (ZIS), University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy; German Federal Institute for Drugs and Medical Devices, Federal Opium Agency.
Nicki-Nils Seitz
Bernd Schulte
Peter Cremer-Schaeffer
Barbara Braun
Uwe Verthein
Tim Pfeiffer-Gerschel
Eötvös Loránd University · HUEssen University Hospital · DEFederal Institute for Drugs and Medical Devices · DEStockholm University · SEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpioid addiction is one of the most common substance-related disorders worldwide, and morbidity and mortality due to opioid addiction place a heavy burden on society. Knowing the size of the population that is addicted to opioids is a prerequisite for the development and implementation of appropriate health-policy measures.

methodsOur estimate for Germany for 2016 is based on an enumeration of opioid-addicted persons who were entered in a registry of persons receiving substitution therapy, an enumeration of persons receiving outpatient and inpatient care for addiction without substitution therapy, an extrapolation to all addiction care facilities, and an estimation of the number of opioid-addicted persons who were not accounted for either in the substitution registry or in addiction care.

resultsThe overall estimate of the number of opioid-addicted persons in Germany in 2016 was 166 294 persons (lower and upper bounds: 164 794 and 167 794), including 123 988 men (122 968 to 125 007) and 42 307 women (41 826 to 42 787). The estimates for each German federal state per 1000 inhabitants ranged from 0.1 in Brandenburg to 3.0 in North Rhine-Westphalia and 5.5 in Bremen. The average value across Germany was 3.1 per 1000 inhabitants.

conclusionComparisons with earlier estimates suggest that the number of persons addicted to opioids in Germany has hardly changed over the past 20 years. Despite methodological limitations, this estimate can be considered highly valid. Nearly all persons who are addicted to opioids are in contact with the addiction care system.

Indexed as

FemaleGermanyHumansMaleOpioid-Related DisordersRegistries

Identifiers

PMID30961791
PMCPMC6460011
OpenAlexW2916561312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.