ArticleMalaria journal2019
Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?
Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic analysis of direct antiglobulin test results in post-artesunate delayed haemolysis.Malaria journal · 2021Pooled it
- The usual suspect-malaria? Diagnostic challenges in post-artesunate delayed haemolysis: a clinical laboratory perspective through a case report.Malaria journal · 2025Review
- Article
- Inhibition of Complement Will Substantially Reduce the Anemia of Malaria.Journal of immunology research · 2025Review
- Acute Kidney Injury and Post-Artesunate Delayed Haemolysis in the Course ofPathogens (Basel, Switzerland) · 2024Article
- Article
- Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers.Journal of travel medicine · 2023Observational
- Plasmodium falciparum-Induced Autoimmune Hemolytic Anemia in a Pregnant Patient with Sickle Cell Disease.The American journal of case reports · 2023Article
- Post-Artesunate Delayed Hemolysis: A Review of Current Evidence.Tropical medicine and infectious disease · 2023Review
- The sting in the tail of severe falciparum malaria: Post-artesunate delayed haemolysis.Southern African journal of infectious diseases · 2022Article
- Fatal case of delayed-onset haemolytic anaemia after oral artemether-lumefantrine.BMJ case reports · 2021Article
- A case of COVID-19 diagnosed with favipiravir-induced drug fever based on a positive drug-induced lymphocyte stimulation test.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- Case Report: Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for UncomplicatedFrontiers in medicine · 2021Article
- Delayed haemolysis following artesunate in a child with profound anaemia and Coca-Cola-coloured urine.BMJ case reports · 2020Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected "pitted" erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. However, an increasing number of cases with positive direct antiglobulin test (DAT) haemolysis after AS have been reported.
methodsAll malaria cases seen at Hospital Clinic of Barcelona between 2015 and 2017 were retrospectively reviewed. Clinical, parasitological and laboratory data from patients treated with intravenous artesunate-specifically looking for delayed haemolysis and DAT-was collected.
resultsAmong the 36 severe malaria patients treated with artesunate at the hospital, 10 (27.8%) developed post-artesunate delayed haemolysis. Out of these, DAT was performed in six, being positive in four of them (at least 40%). DAT was positive only for complement-without IgG-suggesting drug-dependent immune-haemolytic anaemia of the immune-complex type. Three of the four patients were treated with corticosteroids and two also received blood transfusion, with a complete recovery.
conclusionsDrug-induced auto-immune phenomena in post-artesunate delayed haemolysis may be underreported and must be considered. The role of corticosteroids should be reassessed.
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