Evidence map›Paper›PMID 30961267›Full record

ArticlePolymers2018

Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules.

Aaron Alford, Brenna Tucker, Veronika Kozlovskaya, Jun Chen, Nirzari Gupta, Racquel Caviedes, Jenna Gearhart, David Graves, Eugenia Kharlampieva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Research Progress in the Multilayer Hydrogels.Gels (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aaron AlfordDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. aaaron@uab.edu.
Brenna TuckerDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. batucker@uab.edu.
Veronika KozlovskayaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. vkozlovs@uab.edu.
Jun ChenDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. cj1016@uab.edu.
Nirzari GuptaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. nirzari@uab.edu.
Racquel CaviedesDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. racquelc@uab.edu.
Jenna GearhartDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gea7026@student.waynesburg.edu.
David GravesDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. dgraves@uab.edu.
Eugenia KharlampievaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ekharlam@uab.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
National Science Foundation Career Award No. 1350370NCI NIH HHS P30 CA013148
6 · The paper itself

Abstract

Nucleic acid therapeutics have the potential to be the most effective disease treatment strategy due to their intrinsic precision and selectivity for coding highly specific biological processes. However, freely administered nucleic acids of any type are quickly destroyed or rendered inert by a host of defense mechanisms in the body. In this work, we address the challenge of using nucleic acids as drugs by preparing stimuli responsive poly(methacrylic acid)/poly(

Indexed as

DNAhydrogelhydrogen-bondedlayer-by-layermicrocapsulesmultilayer capsulesultrasound

Identifiers

PMID30961267
PMCPMC6401949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.