Evidence map›Paper›PMID 30961261›Full record

ArticlePolymers2018

Polyelectrolyte-Coated Gold Nanoparticles: The Effect of Salt and Polyelectrolyte Concentration on Colloidal Stability.

Melanie Fuller, Ingo Kӧper

Abstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  16. High Stability Au NPs: From Design to Application in Nanomedicine.International journal of nanomedicine · 2021
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melanie FullerFlinders Institute for Nanoscale Science and Technology, College for Science and Engineering, Flinders University, Bedford Park 5042, South Australia. melanie.fuller@flinders.edu.au.ORCID 0000-0002-3529-6468
Ingo KӧperFlinders Institute for Nanoscale Science and Technology, College for Science and Engineering, Flinders University, Bedford Park 5042, South Australia. ingo.koeper@flinders.edu.au.ORCID 0000-0002-5933-6495

Funding

Australian Institute of Nuclear Science and Engineering PGRA scholarship
6 · The paper itself

Abstract

Gold nanoparticles are widely used in biomedical applications. Their ease of surface modification, biocompatibility and the presence of surface plasmons makes them ideal tools for a variety of investigations. Polyelectrolyte-coated gold nanoparticles are employed in areas such as imaging, drug delivery and gene therapy; however, it is not well understood how different factors such as the polyelectrolyte and salt concentration affect the coating on the nanoparticles and hence their performance. Here, these parameters were systematically varied and their effect on the stability of the colloidal nanoparticle suspension was monitored. An increase in the polyelectrolyte concentration from 0 to 30 mg/mL led to a red shift of the surface plasmon peak and an increase in the zeta potential. Concentrations between 5 mg/mL and 30 mg/mL resulted in the most stable systems, with 1 mg/mL being the most unstable. Stable nanoparticle suspensions were formed in salt concentrations below 50 mM, while higher concentrations caused colloidal instability and irreversible aggregation.

Indexed as

biomedicalgoldgold nanoparticlespolyelectrolytestability

Identifiers

PMID30961261
PMCPMC6402027

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.