Evidence map›Paper›PMID 30960839›Full record

ArticlePolymers2018

Bioglass-Incorporated Methacrylated Gelatin Cryogel for Regeneration of Bone Defects.

Song Kwon, Seunghun S Lee, A Sivashanmugam, Janet Kwon, Seung Hyun L Kim, Mi Yeon Noh, Seong Keun Kwon, R Jayakumar, Nathaniel S Hwang

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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  5. Development and Characterization of a Novel Composite Hydrogel Biomaterial for Improved Mucoperiosteal Wound Repair.Journal of biomedical materials research. Part B, Applied biomaterials · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Embedded 3D Printing of Cryogel-Based Scaffolds.ACS biomaterials science & engineering · 2023
    Article
  10. Review
  11. Article
  12. Silicon Nitride as a Biomedical Material: An Overview.International journal of molecular sciences · 2022
    Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Song KwonSchool of Chemical and Biological Engineering, the Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea. skwon2675@gmail.com.
Seunghun S LeeInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. lsean@snu.ac.kr.ORCID 0000-0002-9654-8577
A SivashanmugamCenter for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India. sivasa19619@aims.amrita.edu.
Janet KwonInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. jhkwon929@gmail.com.ORCID 0000-0003-2564-8818
Seung Hyun L KimInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. lucykim619@gmail.com.
Mi Yeon NohInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. mno9211@snu.ac.kr.
Seong Keun KwonInterdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Korea. otolarynx@snuh.org.
R JayakumarCenter for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi 682041, India. rjayakumar@aims.amrita.edu.ORCID 0000-0002-0066-4208
Nathaniel S HwangSchool of Chemical and Biological Engineering, the Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea. nshwang@snu.ac.kr.
Seoul National University · KRAmrita Institute of Medical Sciences and Research Centre · IN

Funding

Council of Scientific and Industrial Research 09/963 (0038)2K17-EMR-IDepartment of Science and Technology, Ministry of Science and Technology INT/ROK/IKRI-2/2016/dated on 9/5/2017National Research Foundation of Korea INT/ROK/IKRI-2/2016/dated on 9/5/2017National Research Foundation of Korea NRF-2017K1A3A1A19070731National Research Foundation of Korea NRF-2017M3A9C6031786
6 · The paper itself

Abstract

Cryogels have recently gained interest in the field of tissue engineering as they inherently possess an interconnected macroporous structure. Considered to be suitable for scaffold cryogel fabrication, methacrylated gelatin (GelMA) is a modified form of gelatin valued for its ability to retain cell adhesion site. Bioglass nanoparticles have also attracted attention in the field due to their osteoinductive and osteoconductive behavior. Here, we prepare methacrylated gelatin cryogel with varying concentration of bioglass nanoparticles to study its potential for bone regeneration. We demonstrate that an increase in bioglass concentration in cryogel leads to improved mechanical property and augmented osteogenic differentiation of mesenchymal cells during in vitro testing. Furthermore, in vivo testing in mice cranial defect model shows that highest concentration of bioglass nanoparticles (2.5

Indexed as

bioglassbone tissue engineeringcryogelhydrogelmethacrylated gelatin

Identifiers

PMID30960839
PMCPMC6403913
OpenAlexW2885676022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.