Evidence map›Paper›PMID 30960759›Full record

ReviewPolymers2018

How Green is Your Plasticizer?

Roya Jamarani, Hanno C Erythropel, James A Nicell, Richard L Leask, Milan Marić

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.

  1. Pooled it
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  19. Alteration of the NEpigenomics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Roya JamaraniDepartment of Chemical Engineering, McGill University, 3610 University St, Montréal, QC H3A 0C5, Canada. roya.jamarani@mail.mcgill.ca.
Hanno C ErythropelDepartment of Chemical Engineering, McGill University, 3610 University St, Montréal, QC H3A 0C5, Canada. hanno.erythropel@yale.edu.ORCID 0000-0003-3443-9794
James A NicellDepartment of Civil Engineering & Applied Mechanics, McGill University, 817 Sherbrooke Street West, Montreal, QC H3A 0C3, Canada. jim.nicell@mcgill.ca.ORCID 0000-0003-0119-2967
Richard L LeaskDepartment of Chemical Engineering, McGill University, 3610 University St, Montréal, QC H3A 0C5, Canada. richard.leask@mcgill.ca.
Milan MarićDepartment of Chemical Engineering, McGill University, 3610 University St, Montréal, QC H3A 0C5, Canada. milan.maric@mcgill.ca.ORCID 0000-0002-4984-8761
McGill University · CAYale University · US

Funding

Mitacs IT10967
6 · The paper itself

Abstract

Plasticizers are additives that are used to impart flexibility to polymer blends and improve their processability. Plasticizers are typically not covalently bound to the polymers, allowing them to leach out over time, which results in human exposure and environmental contamination. Phthalates, in particular, have been the subject of increasing concern due to their established ubiquity in the environment and their suspected negative health effects, including endocrine disrupting and anti-androgenic effects. As there is mounting pressure to find safe replacement compounds, this review addresses the design and experimental elements that should be considered in order for a new or existing plasticizer to be considered green. Specifically, a multi-disciplinary and holistic approach should be taken which includes toxicity testing (both in vitro and in vivo), biodegradation testing (with attention to metabolites), as well as leaching studies. Special consideration should also be given to the design stages of producing a new molecule and the synthetic and scale-up processes should also be optimized. Only by taking a multi-faceted approach can a plasticizer be considered truly green.

Indexed as

additivebiodegradationleachingmetabolitesphthalateplasticizertoxicity

Identifiers

PMID30960759
PMCPMC6403783
OpenAlexW2885401443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.