ArticlePolymers2019
Alginate/Gelatin Hydrogels Reinforced with TiO₂ and β-TCP Fabricated by Microextrusion-based Printing for Tissue Regeneration.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- 3D Printing of Hydrophobic API-Infused Alginate-Gelatin Porous Scaffolds Reinforced with TiOACS omega · 2026Article
- Peptide-based rigid nanorod-reinforced gelatin methacryloyl hydrogels for osteochondral regeneration and additive manufacturing.Nature communications · 2025Article
- Article
- Enhancing auricular reconstruction: A biomimetic scaffold with 3D-printed multiscale porous structure utilizing chondrogenic activity ink.Materials today. Bio · 2025Article
- Effects of Hydroxyapatite Additions on Alginate Gelation Kinetics During Cross-Linking.Polymers · 2025Article
- Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing.Pharmaceutics · 2025Article
- 3D-bioprinted alginate-based bioink scaffolds with β-tricalcium phosphate for bone regeneration applications.Journal of dental sciences · 2024Article
- Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiOPharmaceutics · 2024Article
- Rheology as a Tool for Fine-Tuning the Properties of Printable Bioinspired Gels.Molecules (Basel, Switzerland) · 2023Review
- Clindamycin-Loaded Halloysite Nanotubes as the Antibacterial Component of Composite Hydrogel for Bone Repair.Polymers · 2022Article
- Article
- Osteoblast-like Cell Differentiation on 3D-Printed Scaffolds Using Various Concentrations of Tetra-Polymers.Biomimetics (Basel, Switzerland) · 2022Article
- 3D Printing of Calcium Phosphate/Calcium Sulfate with Alginate/Cellulose-Based Scaffolds for Bone Regeneration: Multilayer Fabrication and Characterization.Journal of functional biomaterials · 2022Article
- Towards the Development of 3D-Printed Food: A Rheological and Mechanical Approach.Foods (Basel, Switzerland) · 2022Review
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Reinforcement of Alginate-Gelatin Hydrogels with Bioceramics for Biomedical Applications: A Comparative Study.Gels (Basel, Switzerland) · 2021Article
- Silk fibroin nanofibers: a promising ink additive for extrusion three-dimensional bioprinting.Materials today. Bio · 2020Article
- Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review.Polymers · 2020Review
- Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges.Journal of polymers and the environment · 2020Review
- Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications.Bioengineering (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) printing technologies have become an attractive manufacturing process to fabricate scaffolds in tissue engineering. Recent research has focused on the fabrication of alginate complex shaped structures that closely mimic biological organs or tissues. Alginates can be effectively manufactured into porous three-dimensional networks for tissue engineering applications. However, the structure, mechanical properties, and shape fidelity of 3D-printed alginate hydrogels used for preparing tissue-engineered scaffolds is difficult to control. In this work, the use of alginate/gelatin hydrogels reinforced with TiO₂ and β-tricalcium phosphate was studied to tailor the mechanical properties of 3D-printed hydrogels. The hydrogels reinforced with TiO₂ and β-TCP showed enhanced mechanical properties up to 20 MPa of elastic modulus. Furthermore, the pores of the crosslinked printed structures were measured with an average pore size of 200 μm. Additionally, it was found that as more layers of the design were printed, there was an increase of the line width of the bottom layers due to its viscous deformation. Shrinkage of the design when the hydrogel is crosslinked and freeze dried was also measured and found to be up to 27% from the printed design. Overall, the proposed approach enabled fabrication of 3D-printed alginate scaffolds with adequate physical properties for tissue engineering applications.
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