Evidence map›Paper›PMID 30960214›Full record

ArticlePolymers2019

The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro.

Jie Xu, Xueyan Hu, Siyu Jiang, Yiwei Wang, Roxanne Parungao, Shuangshuang Zheng, Yi Nie, Tianqing Liu, Kedong Song

Abstract read
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
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  5. Article
  6. Review
  7. Article
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  9. Article
  10. Review
  11. Article
  12. [Experimental study on repairing rabbit skull defect with bone morphogenetic protein 2 peptide/functionalized carbon nanotube composite].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie XuState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. xujie172@mail.dlut.edu.cn.
Xueyan HuState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. Huxueyan@mail.dlut.edu.cn.
Siyu JiangState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. syjiang0226@mail.dlut.edu.cn.
Yiwei WangBurns Research Group, ANZAC Research Institute, Concord, University of Sydney, Sydney, NSW 2139, Australia. yiweiwang@anzac.edu.au.
Roxanne ParungaoBurns Research Group, ANZAC Research Institute, Concord, University of Sydney, Sydney, NSW 2139, Australia. rpar4161@uni.sydney.edu.au.
Shuangshuang ZhengZhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China. sszheng@ipezz.ac.cn.
Yi NieZhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, China. ynie@ipe.ac.cn.
Tianqing LiuState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. liutq@dlut.edu.cn.
Kedong SongState Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. kedongsong@dlut.edu.cn.

Funding

the Fok Ying Tung Education Foundation 132027the National Natural Science Foundation of China 31670978/21676041the Natural Science Foundation of Liaoning 20180510028the State Key Laboratory of Fine Chemicals KF1111
6 · The paper itself

Abstract

In this study, composite scaffolds with different multi-walled carbon nanotubes (MWCNTs) content were prepared by freeze-drying. These scaffolds were characterized by scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), porosity, hydrophilicity, mechanical strength, and degradation. The MWCNTs scaffolds were structurally sound and had porous structures that offered ample space for adherence, proliferation, and differentiation of MC3T3-E1 cells, and also supported the transport of nutrients and metabolic waste. CS/Gel/nHAp/0.3%MWCNTs scaffolds provided the best outcomes in terms of scaffold porosity, hydrophilicity, and degradation rate. However, CS/Gel/nHAp/0.6%MWCNTs scaffolds were found to support the optimal growth, homogenous distribution, and biological activity of MC3T3-E1 cells. The excellent properties of CS/Gel/nHAp/0.6%MWCNTs scaffolds for the adhesion, proliferation, and osteogenesis differentiation of MC3T3-E1 cells in vitro highlights the potential applications of this scaffold in bone tissue regeneration.

Indexed as

bone tissue engineeringCS/Gel/nHApMC3T3-E1 cellsMWCNTs

Identifiers

PMID30960214
PMCPMC6419040

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.