ArticlePolymers2019
Patterned Polyvinyl Alcohol Hydrogel Dressings with Stem Cells Seeded for Wound Healing.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Phase-separated hydrogels for advanced biomedical engineering: From material design to applications.Materials today. Bio · 2026Review
- Sustainable ZnO/ZnGels (Basel, Switzerland) · 2026Article
- Synthetic Polymer-Based Interventions in Wound Healing: A Clinical Perspective on their Efficacy and Limitations.Current pharmaceutical design · 2026Review
- Tissue Regeneration of Radiation-Induced Skin Damages Using Protein/Polysaccharide-Based Bioengineered Scaffolds and Adipose-Derived Stem Cells: A Review.International journal of molecular sciences · 2025Review
- Hydrogels and nanogels: effectiveness in dermal applications.Beilstein journal of nanotechnology · 2025Review
- Integration of Functional Polymers and Biosensors to Enhance Wound Healing.Advanced healthcare materials · 2024Review
- Development of Polyvinyl Alcohol Hydrogels for Controlled Glucose Release in Biomedical Applications.Gels (Basel, Switzerland) · 2024Article
- Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: A review.Health science reports · 2024Article
- Effect of Polydopamine and Curcumin on Physicochemical and Mechanical Properties of Polymeric Blends.Materials (Basel, Switzerland) · 2023Article
- A novel nanocomposite containing zinc ferrite nanoparticles embedded in carboxymethylcellulose hydrogel plus carbon nitride nanosheets with multifunctional bioactivity.RSC advances · 2023Article
- A Brief Review on Cerium Oxide (CeOMicromachines · 2023Review
- pH-Responsive PVA-Based Nanofibers Containing GO Modified with Ag Nanoparticles: Physico-Chemical Characterization, Wound Dressing, and Drug Delivery.Micromachines · 2022Article
- Alkaline Treatment Variables to Characterize Poly(Vinyl Alcohol)/Poly(Vinyl Butyral/Vinyl Alcohol) Blend Films.Polymers · 2022Article
- Photoreactive Hydrogel Stiffness Influences Volumetric Muscle Loss Repair.Tissue engineering. Part A · 2022Article
- Effects of poly(vinyl alcohol) blending with Ag/alginate solutions to form nanocomposite fibres for potential use as antibacterial wound dressings.Royal Society open science · 2022Article
- An Absorbent, Flexible, Transparent, and Scalable Substrate for Wound Dressings.IEEE journal of translational engineering in health and medicine · 2022Article
- Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications.International journal of biomaterials · 2022Review
- In Vitro Wound Dressing Stack Model as a First Step to Evaluate the Behavior of Dressing Materials in Wound Bed-An Assessment of Mass Transport Phenomena in Hydrogel Wound Dressings.Materials (Basel, Switzerland) · 2021Article
- A freeze-thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties.RSC advances · 2021Article
- Recent trends on wound management: New therapeutic choices based on polymeric carriers.Asian journal of pharmaceutical sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Polyvinyl alcohol (PVA) hydrogel and stem cell therapy have been widely used in wound healing. However, the lack of bioactivity for PVA and security of stem therapy limited their application. In this study, an adipose-derived stem cells (ADSCs)-seeded PVA dressing (ADSCs/PVA) was prepared for wound healing. One side of the PVA dressing was modified with photo-reactive gelatin (Az-Gel) via ultraviolet (UV) irradiation (Az-Gel@PVA), and thus ADSCs could adhere, proliferate on the PVA dressings and keep the other side of the dressings without adhering to the wound. The structure and mechanics of Az-Gel@PVA were determined by scanning electron microscopy (SEM) and material testing instruments. Then, the adhesion and proliferation of ADSCs were observed via cell counts and live-dead staining. Finally, in vitro and in vivo experiments were utilized to confirm the effect of ADSCs/PVA dressing for wound healing. The results showed that Az-Gel was immobilized on the PVA and showed little effect on the mechanical properties of PVA hydrogels. The surface-modified PVA could facilitate ADSCs adhesion and proliferation. Protein released tests indicated that the bioactive factors secreted from ADSCs could penetrated to the wound. Finally, in vitro and in vivo experiments both suggested the ADSCs/PVA could promote the wound healing via secreting bioactive factors from ADSCs. It was speculated that the ADSCs/PVA dressing could not only promote the wound healing, but also provide a new way for the safe application of stem cells, which would be of great potential for skin tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.