Evidence map›Paper›PMID 30959979›Full record

ArticleJournal of clinical medicine2019

Anatomical and Functional Changes of the Retina and the Choroid after Resolved Chronic CSCR.

Lisa Toto, Rossella D'Aloisio, Rodolfo Mastropasqua, Luca Di Antonio, Marta Di Nicola, Giuseppe Di Martino, Federica Evangelista, Emanuele Erroi, Emanuele Doronzo, Cesare Mariotti

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lisa TotoOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. l.toto@unich.it.
Rossella D'AloisioOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. ross.daloisio@gmail.com.
Rodolfo MastropasquaVitreoretinal Unit, Bristol Eye Hospital, University of Bristol, Bristol, BS1 4TB, UK. rodolfo.mastropasqua@gmail.com.
Luca Di AntonioOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. monsieurluca@yahoo.com.
Marta Di NicolaDepartment of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. marta.dinicola@unich.it.
Giuseppe Di MartinoDepartment of Medicine and Science of Ageing, School of Hygiene and Preventive Medicine, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. peppinodimartino@hotmail.com.ORCID 0000-0001-7047-7611
Federica EvangelistaOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. federica.evan@hotmail.com.
Emanuele ErroiOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. erroi.emanuele@gmail.com.
Emanuele DoronzoOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, 66100 Chieti, Italy. doronzo.oculista@libero.it.
Cesare MariottiEye Clinic, Polytechnic University of Marche, 60126 Ancona, Italy. mariottic@libero.it.
University of Chieti-Pescara · ITMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate anatomical/functional changes after oral eplerenone therapy for chronic central serous chorioretinopathy (CCSC) in successfully treated eyes and fellow eyes and assess timing of foveal subretinal fluid (SRF) resolution.

methodsTwenty-one eyes of 21 patients suffering from CCSC with monolateral foveal SRF successfully treated with oral eplerenone were enrolled in this retrospective study (group 1). The fellow eyes (21 eyes; group 2), healthy or affected by CCSC, without foveal SRF were considered in the analysis. A control healthy group was enrolled as well (healthy controls;

resultsFunctional and anatomical parameters significantly improved during the study in group 1. BCVA increased significantly (

conclusionsEplerenone treatment in chronic CSCR potentially improves recovery of retinal and choroidal morphology as well as visual acuity gain. A complete resolution of foveal SRF was observed in all eyes during a 4-month follow-up, with most eyes healing at 2 months.

Indexed as

choriocapillaris densitychronic central serous chorioretinopathyeplerenone therapyoptical coherence tomography angiographysubfoveal choroidal thicknesssuperficial capillary plexus density

Identifiers

PMID30959979
PMCPMC6517936
OpenAlexW2927573035

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.